A monoclonal antibody defining antigenic determinants on subpopulations of mammalian neurones and Trypanosoma cruzi parasites
A monoclonal antibody defining antigenic determinants on subpopulations of mammalian neurones and Trypanosoma cruzi parasites
复制标题
确定哺乳动物神经元和克氏锥虫寄生虫亚群抗原决定簇的单克隆抗体
作者：
J. Wood;L. Hudson;T. M. Jessell;T. M. Jessell;Masayuki Yamamoto;Masayuki Yamamoto
针对大鼠背根神经节膜的IgM λ类单克隆抗体定义了哺乳动物中枢和外周神经元亚群表达的新抗原决定簇。在补体存在下，抗体在体外对哺乳动物神经元具有细胞毒性。相同的抗体标记克氏锥虫，这种原生动物负责查加斯病。已知被抗体标记的哺乳动物神经元和心肌类别在恰加斯病中退化。因此，由抗体识别的常见神经元和锥虫抗原在这种疾病的致病事件中可能是重要的。
An IgM λ class monoclonal antibody raised against membranes from rat dorsal root ganglia defines a novel antigenic determinant expressed by subpopulations of mammalian central and peripheral neurones. In the presence of complement the antibody is cytotoxic to mammalian neurones in vitro. The same antibody labels Trypanosoma cruzi, the protozoan responsible for Chagas' disease. Classes of mammalian neurones and cardiac muscle that are labelled by the antibody are known to degenerate in Chagas' disease. The common neuronal and trypanosomal antigens recognized by the antibody may therefore be important in pathogenic events underlying this disorder.