OVCA1 inhibits the proliferation of epithelial ovarian cancer cells by decreasing cyclin D1 and increasing p16
OVCA1 inhibits the proliferation of epithelial ovarian cancer cells by decreasing cyclin D1 and increasing p16
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DOI：
10.1007/s11010-011-0819-0
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发表时间：
2011-08-01
影响因子：
4.3
通讯作者：
Zhao, Chunyan
中科院分区：
文献类型：
--
作者：
Kong, Fandou;Tong, Rui;Zhao, Chunyan
OVCA 1是一种肿瘤抑制基因，在约80%的卵巢癌中缺失或低表达。OVCA 1在人卵巢癌A2780细胞中的过表达抑制细胞增殖并使细胞停滞于G1期。然而，OVCA 1抑制细胞生长的分子机制目前尚不清楚。在这里，我们研究了潜在的信号通路诱导OVCA 1的过度表达。我们的研究结果表明，人OVCA 1在卵巢癌细胞A2780中的过表达导致cyclin D1的表达下调，p16的表达上调，但对NF-κ B B的表达没有影响。提示OVCA 1可通过p16/cyclin D1途径抑制卵巢癌细胞A2780的增殖，而不通过NF-κ B B途径。
OVCA1, a tumor suppressor gene, is deleted or lower expressed in about 80% of ovarian cancer. Over expression of OVCA1 in human ovarian cancer A2780 cells inhibits cell proliferation and arrests cells in G1 stage. However, the fact that the molecular mechanism of OVCA1 inhibits cell growth is presently elusive. Here we investigated the potential signaling pathway induced by over-expression of OVCA1. Our results show that over-expression of human OVCA1 in ovarian cancer cells A2780 leads to down-regulation of cyclin D1, and up-regulation of p16, but no effect on the expression of NF-kappa B. It indicates that OVCA1 could inhibit the proliferation of ovarian cancer cell A2780 by p16/cyclin D1 pathway, but not by NF-kappa B.