The Yin and Yang of Pneumolysin During Pneumococcal Infection.
The Yin and Yang of Pneumolysin During Pneumococcal Infection.
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DOI：
10.3389/fimmu.2022.878244
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
肺炎链球菌溶血素（Streptococcus pneumonia，简称pneumonia）是由人类致病性肺炎链球菌（Streptococcus pneumonia，简称pneumonia）产生的一种致孔毒素。肺炎球菌的一个关键毒力因子，能在宿主细胞中形成跨膜孔，破坏质膜的完整性和失调细胞内稳态。在裂解浓度下，β-内酰胺酶导致细胞死亡。在亚裂解浓度下，β-内酰胺酶触发宿主细胞存活途径，这些途径合作重新密封受损的质膜并恢复细胞内稳态。而β-淀粉酶通常被认为是促进S.除了促进肺炎链球菌定植和存活外，它也是针对细菌感染的先天性和适应性宿主免疫应答的有力触发剂。作为关键的细菌毒力因子和宿主免疫调节的触发剂的毒素的二分法允许毒素在感染期间显示“阴”和“阳”性质，通过膜穿孔和激活炎症途径促进疾病，同时还通过触发宿主细胞修复和启动抗炎反应来减轻损伤。由于其细胞溶解活性和多种免疫调节特性，它是S.肺炎的发病机制，并可能倾向于平衡的病原体或主机取决于感染的情况。
Pneumolysin (PLY) is a pore-forming toxin produced by the human pathobiont Streptococcus pneumoniae, the major cause of pneumonia worldwide. PLY, a key pneumococcal virulence factor, can form transmembrane pores in host cells, disrupting plasma membrane integrity and deregulating cellular homeostasis. At lytic concentrations, PLY causes cell death. At sub-lytic concentrations, PLY triggers host cell survival pathways that cooperate to reseal the damaged plasma membrane and restore cell homeostasis. While PLY is generally considered a pivotal factor promoting S. pneumoniae colonization and survival, it is also a powerful trigger of the innate and adaptive host immune response against bacterial infection. The dichotomy of PLY as both a key bacterial virulence factor and a trigger for host immune modulation allows the toxin to display both “Yin” and “Yang” properties during infection, promoting disease by membrane perforation and activating inflammatory pathways, while also mitigating damage by triggering host cell repair and initiating anti-inflammatory responses. Due to its cytolytic activity and diverse immunomodulatory properties, PLY is integral to every stage of S. pneumoniae pathogenesis and may tip the balance towards either the pathogen or the host depending on the context of infection.
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影响因子：
6.7
作者：
Alhamdi Y;Neill DR;Abrams ST;Malak HA;Yahya R;Barrett-Jolley R;Wang G;Kadioglu A;Toh CH
通讯作者：
Toh CH
影响因子：
6.4
作者：
Beno, Sarah M.;Riegler, Ashleigh N.;Orihuela, Carlos J.
通讯作者：
Orihuela, Carlos J.
影响因子：
5.8
作者：
Boxio R;Wartelle J;Nawrocki-Raby B;Lagrange B;Malleret L;Hirche T;Taggart C;Pacheco Y;Devouassoux G;Bentaher A
通讯作者：
Bentaher A
影响因子：
5.8
作者：
Bandara M;Skehel JM;Kadioglu A;Collinson I;Nobbs AH;Blocker AJ;Jenkinson HF
通讯作者：
Jenkinson HF
影响因子：
5.5
作者：
Beurg, M;Hafidi, A;Dulon, D
通讯作者：
Dulon, D