The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis.
The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis.
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DOI：
10.1155/2015/468627
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发表时间：
2015
影响因子：
4.3
通讯作者：
Mani A
中科院分区：
文献类型：
--
作者：
Wang S;Song K;Srivastava R;Fathzadeh M;Li N;Mani A
背景关于转录因子7样2（TCF7L2）变体rs7903146与血脂异常相关性的已发表研究结果相互矛盾且不确定。方法.我们利用电子数据库和已发表的研究进行了一项荟萃分析，旨在研究rs7903146变异与血脂水平的相关性。通过标准算法提取数据。利用显性、隐性、纯合子和杂合子比较模型。结果本荟萃分析纳入了24项研究，共纳入52，785例受试者。总的来说，次要等位基因（T）与2型糖尿病受试者的高甘油三酯血症风险降低相关（显性模型：SMD = − 0.04，95% CI（− 0.08，0.00），P = 0.048，P异质性= 0.47;隐性模型：SMD = − 0.10，95% CI（− 0.18，− 0.02），P = 0.01，P异质性= 0.56）。在2型糖尿病或代谢综合征（MetS）受试者中未发现次要（T）等位基因与血浆TC、LDL-c或HDL-c水平相关，在非糖尿病受试者中未发现次要（T）等位基因与血浆TG水平相关。结论.我们的荟萃分析表明TCF7L2 rs7903146多态性与2型糖尿病受试者的低血浆甘油三酯（TG）水平相关。在非糖尿病受试者中，未发现rs7903146变异体与血脂之间存在关联。
Background. The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) variant rs7903146 with dyslipidemia have been conflicting and inconclusive. Methods. We carried out a meta-analysis that aimed to investigate the association of the rs7903146 variant with plasma lipid levels using electronic database and published studies. Data was extracted by a standard algorithm. Dominant, recessive, homozygote, and heterozygote comparison models were utilized. Results. 24 studies incorporating 52,785 subjects were included in this meta-analysis. Overall, the minor allele (T) was associated with lower risk for hypertriglyceridemia in subjects with type 2 diabetes (dominant model: SMD = −0.04, 95% CI (−0.08, 0.00), P = 0.048, P heterogeneity = 0.47; recessive model: SMD = −0.10, 95% CI (−0.18, −0.02), P = 0.01, P heterogeneity = 0.56). No association was found between minor (T) allele and plasma TC, LDL-c, or HDL-c levels in subjects with type 2 diabetes or metabolic syndrome (MetS) and no association was found between minor (T) allele and plasma TG levels in nondiabetic subjects. Conclusions. Our meta-analysis indicated the association between TCF7L2 rs7903146 polymorphism and low plasma triglyceride (TG) level in subjects with type 2 diabetes. No association was found between rs7903146 variant and plasma lipids in nondiabetic subjects.