Association between serum Klotho concentration and heart failure in adults, a cross-sectional study from NHANES 2007-2016
Association between serum Klotho concentration and heart failure in adults, a cross-sectional study from NHANES 2007-2016
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DOI：
10.1016/j.ijcard.2022.11.010
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发表时间：
2022-12-08
影响因子：
3.5
通讯作者：
Song, Bin
中科院分区：
文献类型：
--
作者：
Cai, Jiasheng;Zhang, Lingyun;Song, Bin
背景：关于血清Klotho浓度与心力衰竭（HF）之间关系的数据有限。方法与结果：我们对2007-2016年国家健康和营养检查调查（NHANES）中的13，625名40-79岁的参与者进行了横断面研究。多变量逻辑回归模型用于检查血清Klotho浓度（ln转换）和HF之间的关联。共有533名（2.9%）参与者被确定患有HF，血清Klotho浓度最低的三分位数参与者的HF百分比最高（T1：3.8% vs. T2：2.8%和T3：2.1%，P < 0.001）。校正潜在混杂因素后，ln（Klotho）与HF风险呈独立负相关（OR= 0.55，95%CI 0.36-0.84）。同时，与T1组相比，血清Klotho浓度越高，发生HF的风险越低（三分位数2：OR = 0.93，95%CI：0.69-1.29;三分位数3：OR = 0.75，95%CI：0.52-1.09，趋势P = 0.022）。最后，亚组分析表明，在一半的亚组中，较低的Klotho浓度与HF风险增加显著相关。结论：在美国中年和老年人中，血清Klotho浓度与HF的存在一致且呈负相关。
Background: Limited data exist on the association between serum Klotho concentration and heart failure (HF). Methods and results: We conducted a cross-sectional study of 13,625 participants aged 40-79 years in the National Health and Nutrition Examination Survey (NHANES) 2007-2016. Multivariable logistic regression models were used to examine the association between serum Klotho concentration (ln transformation) and HF. A total of 533 (2.9%) participants were identified to have HF, and participants with the lowest tertiles of serum Klotho con-centration had the highest percentage of HF (T1: 3.8% vs. T2: 2.8% and T3: 2.1%, P < 0.001). After adjusting for potential confounders, ln (Klotho) was negatively and independently associated with the risk of HF (OR= 0.55, 95% CI 0.36-0.84). Meanwhile, compared with the T1 group, a higher serum Klotho concentration was asso-ciated with a lower risk of HF (tertile 2: OR = 0.93, 95% CI: 0.69-1.29, tertile 3: OR = 0.75, 95% CI: 0.52-1.09, P for trend 0.022). Finally, subgroup analyses indicated that lower Klotho concentrations significantly correlated with an increased risk of HF in half of the subgroups. Conclusion: Serum Klotho concentration was consistently and negatively associated with the presence of HF among US middle-aged and older adults.