Endothelin has potent inotropic effects in rat atria.
Endothelin has potent inotropic effects in rat atria.
复制标题
内皮素对大鼠心房具有有效的正性肌力作用。
DOI：
10.1016/0014-2999(88)90079-9
复制
发表时间：
1988
影响因子：
5
通讯作者：
R. Lang
中科院分区：
文献类型：
--
作者：
J. Hu;R. von Harsdorf;R. Lang
内皮素是近年来从主动脉内皮细胞中分离得到的一种新的缩血管活性肽。我们报告，内皮素也是一个非常强大的正性肌力物质，在离体大鼠心房证明。在纳摩尔浓度下观察到这种作用，似乎是由于肽对心肌细胞的直接作用。因此，内皮素不仅是一种强有力的血管收缩剂，而且对心肌细胞具有强有力的收缩作用。
Endothelin, a novel peptide recently isolated from aortic endothelial cells, is one of the most active vasoconstrictors yet characterized. We report that endothelin is also a very potent inotropic substance, as demonstrated in isolated rat heart atria. The effects were observed at nanomolar concentrations and appeared to be due to a direct action of the peptide on the heart muscle cells. Thus, endothelin is not only a powerful vasoconstrictor but also has potent contractile effects on cardiac myocytes.