Legumain Protein as a Potential Predictive Biomarker for Asian Patients with Breast Carcinoma
Legumain Protein as a Potential Predictive Biomarker for Asian Patients with Breast Carcinoma
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DOI：
10.7314/apjcp.2014.15.24.10773
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发表时间：
2014-01-01
影响因子：
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通讯作者：
Ruan, Zheng-Min
中科院分区：
文献类型：
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作者：
Wu, Mei;Shao, Guang-Rui;Ruan, Zheng-Min
背景：乳腺癌的治疗主要是通过手术切除原发肿瘤和化疗。然而，乳腺癌在发生浸润和转移后，很难控制。阐明乳腺癌的发病机制将有助于乳腺癌的预后和治疗。本研究的目的是探讨legumain蛋白的临床和预后的影响材料和方法：在这项研究中，我们检查了乳房切除标本114乳腺癌和匹配，26个相邻的非癌组织，使用免疫组化。结果如下：结果表明，Legumain蛋白在乳腺癌组织中的阳性表达率为51.8%（59/114），在癌旁组织中的阳性表达率为11.5%（3/26）。Legumain表达与乳腺癌的淋巴结转移有关（p=0.02），相关分析显示Legumain表达与雌激素受体（ER）和mu型p53表达呈正相关（均为p
Background: Treatment for breast cancer is mainly performed by surgical resection of primary tumors and chemotherapy. However, after tumor invasion and metastases, breast cancer is hard to control. Clarification of the pathogenic mechanisms would be helpful to the prognosis or therapy for the breast cancer. The aim of this study is to investigate the clinical and prognostic implications of legumain protein Materials and Methods: In this study, we examined mastectomy specimens from 114 breast cancer and matching, 26 adjacent non-cancerous tissues using immunohistochemistry. Results: The results indicated that positive expression of legumain protein in breast cancer was 51.8 % (59/114) and the positive expression of legumain protein in adjacent non-cancerous tissue was 11.5% (3/26). It appeared to be related with lymph node metastasis of breast cancer (p=0.02) and correlation analysis indicated that legumain expression was correlated positively with the estrogen receptor (ER) and mutant-type p53 expression (both p