Serum level of neopterin is not a marker of disease activity in treated rheumatoid arthritis patients
Serum level of neopterin is not a marker of disease activity in treated rheumatoid arthritis patients
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DOI：
10.1007/s10067-016-3433-4
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发表时间：
2017-09-01
影响因子：
3.4
通讯作者：
Mohammed, Asmaa M.
中科院分区：
文献类型：
--
作者：
El-Lebedy, Dalia;Hussein, Jihan;Mohammed, Asmaa M.
新蝶呤在许多自身免疫性疾病中被检测到，并被报道为类风湿性关节炎（RA）中细胞免疫激活的标志物。这项工作的目的是评估血清新蝶呤作为疾病活动的标志物治疗RA患者。采用高效液相色谱法（HPLC）检测120例RA患者和100例年龄、性别匹配的对照者血清新喋呤水平，并采用DAS 28-CRP评分计算所有患者的疾病活动度评分。与健康对照组（4.74 +/- 1.98 nmol/L）相比，RA患者（11.46 +/- 3.56 nmol/L）的新蝶呤水平显著更高，P < 0.0001。男性RA患者的新蝶呤水平[中位数（IQR），13.44（12.65-16.21）]显著高于女性RA患者[中位数（IQR），11.86（7.91-13.44）]，P < 0.0001。新蝶呤与年龄、发病年龄、病程或任何疾病活动参数之间均无显著相关性，而且，不同疾病活动阶段的新蝶呤水平也无显著差异。我们的研究结果表明，新蝶呤是一个标记的RA，但不是一个标记的疾病活动在治疗RA患者。
Neopterin has been measured in many autoimmune diseases and was reported as a marker of cellular immunity activation in rheumatoid asthritis (RA). The aim of this work was to assess serum neopterin as a marker of disease activity in treated RA patients. We measured serum level of neopterin in 120 treated RA patients and 100 age- and sex-matched controls by high-performance liquid chromatography (HPLC) method, and disease activity score was calculated in all patients by DAS28-CRP score. Significantly higher levels of neopterin were observed in RA patients (11.46 +/- 3.56 nmol/L) compared to healthy controls (4.74 +/- 1.98 nmol/L), P < 0.0001. Significantly higher neopterin levels were observed among male RA patients [median (IQR), 13.44 (12.65-16.21)] than female RA patients [median (IQR), 11.86 (7.91-13.44)], P < 0.0001. No significant correlations between neopterin and age, age of disease onset, disease duration, or any of the disease activity parameters were found. Moreover, no significant difference regarding neopterin levels in different disease activity phases was identified. Our results indicated that neopterin is a marker of RA but not a marker of disease activity in treated RA patients.