MYOSIN ISOFORM TRANSITIONS IN REGENERATION OF FAST AND SLOW MUSCLES DURING POSTNATAL-DEVELOPMENT OF THE RAT
MYOSIN ISOFORM TRANSITIONS IN REGENERATION OF FAST AND SLOW MUSCLES DURING POSTNATAL-DEVELOPMENT OF THE RAT
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DOI：
10.1016/0012-1606(89)90182-6
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发表时间：
1989-10-01
影响因子：
2.7
通讯作者：
MIRA, JC
中科院分区：
文献类型：
--
作者：
DALBIS, A;COUTEAUX, R;MIRA, JC
在大鼠出生后第1周，通过在后腿注射心脏毒素实现肌纤维变性后，观察大鼠快肌（腓肠肌内侧肌）和慢肌（比目鱼肌）的再生情况。再生肌肉的肌肉发生与出生后对侧和对照肌肉的肌肉发生进行了比较。胚胎和新生儿肌球蛋白异构体的合成在损伤后3天开始。这些形式逐渐被中间和快速的成人同种异构体（II型纤维肌球蛋白）所取代，其合成在再生肌肉、对侧肌肉和对照肌肉中遵循相同的曲线。相比之下，慢速肌球蛋白异构体（I型纤维肌球蛋白）的合成在损伤肌肉中被大大延迟，但最终与对侧和对照肌肉的合成相同。因此，在发育再生和正常肌肉中，II型纤维肌球蛋白的合成可能受到甲状腺激素的类似调节，而I型纤维肌球蛋白的合成则取决于其他因素。
Regeneration of rat fast (gastrocnemius medialis) and slow (soleus) muscles was examined after degeneration of myofibers had been achieved by injection of cardiotoxin into the hindleg during the first week after birth. Myogenesis in the regenerating muscles was compared to postnatal myogenesis in the contralateral and in control muscles. Synthesis of embryonic and neonatal myosin isoforms was initiated 3 days after injury. These forms were gradually replaced by the intermediate and fast adult isoforms (type II fiber myosins), whose synthesis followed the same curve in regenerating, contralateral, and control muscles. In contrast, synthesis of the slow myosin isoform (type I fiber myosin) was greatly delayed in injured muscles, but eventually became equal to its synthesis to its synthesis in contralateral and control muscles. It therefore appears that synthesis of type II fiber myosins is similarly regulated, probably by thyroid hormone, in developing regenerating and normal muscles, while synthesis of type I fiber myosin depends on other factor(s).