Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunization.
Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunization.
复制标题
慢性感染猿猴免疫缺陷病毒 SIVmac251 的猕猴在接受治疗性 DNA 免疫后，病毒血症持续减少。
DOI：
10.1128/jvi.01990-06
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发表时间：
2007
影响因子：
5.4
通讯作者：
Eldridge,John
中科院分区：
文献类型：
--
作者：
vonGegerfelt,AgnetaS;Rosati,Margherita;Alicea,Candido;Valentin,Antonio;Roth,Patricia;Bear,Jenifer;Franchini,Genoveffa;Albert,PaulS;Bischofberger,Norbert;Boyer,JeanD;Weiner,DavidB;Markham,Phillip;Israel,ZimraR;Eldridge,John
Rhesus macaques chronically infected with highly pathogenic simian immunodeficiency virus (SIV) SIVmac251 were treated with antiretroviral drugs and vaccinated with combinations of DNA vectors expressing SIV antigens. Vaccination during therapy increased cellular immune responses. After the animals were released from therapy, the virus levels of 12 immunized animals were significantly lower (P= 0.001) compared to those of 11 animals treated with only antiretroviral drugs. Vaccinated animals showed a persistent increase in immune responses, thus indicating both a virological and an immunological benefit following DNA therapeutic vaccination. Several animals show a long-lasting decrease in viremia, suggesting that therapeutic vaccination may provide an additional benefit to antiretroviral therapy.
