Elevated level of nerve growth factor in the bladder pain syndrome/interstitial cystitis: a meta-analysis.
Elevated level of nerve growth factor in the bladder pain syndrome/interstitial cystitis: a meta-analysis.
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膀胱疼痛综合征/间质性膀胱炎的神经生长因子水平升高：一项荟萃分析。
DOI：
10.1186/s40064-016-2719-y
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Liang Y
中科院分区：
文献类型：
--
作者：
Chen W;Ye DY;Han DJ;Fu GQ;Zeng X;Lin W;Liang Y
通过Meta分析，阐明神经生长因子（NGF）水平与膀胱疼痛综合征/间质性膀胱炎（BPS/IC）之间的关系。我们进行了系统的文献检索，以确定2015年11月之前BPS/IC中NGF水平的原始研究。通过计算机检索和手动查阅参考文献检索符合条件的研究。根据加权平均差（WMD）及其95%置信区间（CI）计算对照组和BPS/IC组之间的汇总差异估计值。在汇总分析后进行敏感性和发表分析。Meta分析10个原始文献，包括295例BPS/IC患者和290例正常对照，结果显示BPS/IC患者尿NGF水平升高（z = 3.08，P = 0.002）。合并WMD为36.39（95% CI 13.27-59.51）。BPS/IC组与对照组比较，差异有显著性意义（WMD = 0.96，95%CI0.58 -1.35; z = 4.89，P < 0.01）。在纳入的研究中没有显著的出版偏倚（Begg检验P = 0.73，Egger检验P = 0.13）。我们的研究结果表明，在BPS/IC患者中存在增加的NGF水平。
To elucidate the association between nerve growth factor (NGF) level and bladder pain syndrome/interstitial cystitis (BPS/IC) by conducting a meta-analysis. We conducted a systematic literature search to identify original studies of NGF level in BPS/IC before November 2015. Eligible studies were retrieved via both computer searches and manual review of references. The summary difference estimates between controlled group and BPS/IC group were calculated based on the weighted mean difference (WMD) with its 95 % confidence interval (CI). Sensitivity and publication analyses were performed after the pooled analysis. Meta-analysis of 10 original studies involving 295 cases and 290 normal controls showed an increased level of urinary NGF in BPS/IC patients (z = 3.08, P = 0.002). The combined WMD was 36.39 (95 % CI 13.27–59.51). There was significant difference between controlled group and BPS/IC patients in the term of NGF/Cr level (WMD = 0.96, 95 % CI 0.58–1.35; z = 4.89, P < 0.01). There was no significant publication bias in the included studies (P for Begg’s test = 0.73, P for egger’s test = 0.13). Our results demonstrated that there was an increased level of NGF in the BPS/IC patients.