Visual and vergence eye movement-related responses of pursuit neurons in the caudal frontal eye fields to motion-in-depth stimuli
Visual and vergence eye movement-related responses of pursuit neurons in the caudal frontal eye fields to motion-in-depth stimuli
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DOI：
10.1007/s00221-004-2213-6
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发表时间：
2005-07-01
影响因子：
2
通讯作者：
Fukushima, K
中科院分区：
文献类型：
--
作者：
Akao, T;Kurkin, SA;Fukushima, K
额叶眼场(FEF)的尾部含有与平滑追踪相关的神经元。以往的研究表明，大多数FEF追踪神经元在平滑追踪开始前携带与额叶斑点运动和放电有关的视觉信号。也有研究表明，在收敛跟踪过程中，大多数FEF追踪神经元都会放电。精确的收敛跟踪需要关于目标深度运动的信息。为了进一步了解FEF在聚焦跟踪中的作用，并确定FEF追踪神经元是否携带目标深度运动的视觉信息，我们研究了FEF追踪神经元对正弦点深度运动的视觉和会聚眼动相关反应。在收敛跟踪过程中，大多数FEF追踪神经元同时表现出收敛眼位和速度敏感度。大多数神经元的相移(Re靶速度)在1.5赫兹时几乎保持不变。大约一半的FEF追踪神经元表现出对深度运动斑点的视觉反应。大多数神经元的视觉反应的首选方向与收敛跟踪时的方向相似。其中大多数神经元的视觉反应对点深度运动的速度很敏感。大多数反应神经元的相移在2.0赫兹时基本保持不变。深入表现视觉反应的神经元与在额面表现视觉反应的神经元大多是分开的。为了进一步研究FEF追踪神经元是否可以参与收敛跟踪的启动，我们检测了神经元对步进目标纵深运动诱导的会聚眼球运动的反应潜伏期。约有一半的FEF追踪神经元在眼球会聚运动开始前放电，其引导时间超过20ms。这些结果结合以前的观察结果表明，尾侧FEF携带着适当的视觉信号，可以转化为运动指令，用于在纵深和额面进行追逐。
The caudal parts of the frontal eye fields (FEF) contain smooth-pursuit related neurons. Previous studies show that most FEF pursuit neurons carry visual signals in relation to frontal spot motion and discharge before the initiation of smooth-pursuit. It has also been demonstrated that most FEF pursuit neurons discharge during vergence tracking. Accurate vergence tracking requires information about target motion-in-depth. To further understand the role of the FEF in vergence tracking and to determine whether FEF pursuit neurons carry visual information about target motion-in-depth, we examined visual and vergence eye movement-related responses of FEF pursuit neurons to sinusoidal spot motion-in-depth. During vergence tracking, most FEF pursuit neurons exhibited both vergence eye position and velocity sensitivity. Phase shifts (re target velocity) of most neurons remained virtually constant up to 1.5 Hz. About half of FEF pursuit neurons exhibited visual responses to spot motion-in-depth. The preferred directions for visual responses of most neurons were similar to those during vergence tracking. Visual responses of most of these neurons exhibited sensitivity to the velocity of spot motion-in-depth. Phase shifts of most of the responding neurons remained virtually constant up to 2.0 Hz. Neurons that exhibited visual responses in-depth were mostly separate from neurons that showed visual responses in the frontal plane. To further examine whether FEF pursuit neurons could participate in initiation of vergence tracking, we examined latencies of neuronal responses with respect to vergence eye movements induced by step target motion-in-depth. About half of FEF pursuit neurons discharged before the onset of vergence eye movements with lead times longer than 20 ms. These results together with previous observations suggest that the caudal FEF carries visual signals appropriate to be converted into motor commands for pursuit in depth and frontal plane.