MULTIPLE MALIGNANT ASTROCYTOMAS IN A PATIENT WITH SPONTANEOUS PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY
MULTIPLE MALIGNANT ASTROCYTOMAS IN A PATIENT WITH SPONTANEOUS PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY
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DOI：
10.1002/ana.410140205
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发表时间：
1983-01-01
影响因子：
11.2
通讯作者：
MCLACHLAN, DR
中科院分区：
文献类型：
--
作者：
SIMA, AAF;FINKELSTEIN, SD;MCLACHLAN, DR
一名67岁的男性，有4年的水平和垂直眼球震颤和进行性小脑功能障碍的病史，后来发展为严重痴呆并死于支气管肺炎。神经病理学检查显示大脑和小脑有大量活动性和非活动性进行性多灶性白质脑病(PML)病变。活动性病变可见明显的血管周围淋巴细胞性袖套。在少突胶质细胞和星形胶质细胞的超微结构中都发现了乳头病毒。多个恶性星形细胞瘤被记录，起源于PML病变。在肿瘤星形胶质细胞中未发现病毒。临床或尸检均未发现免疫缺陷状态。
A 67 yr old man with a 4-yr history of horizontal and vertical nystagmus and progressive cerebellar dysfunction later developed profound dementia and died of bronchopneumonia. Neuropathological examination revealed numerous active and inactive progressive multifocal leukoencephalopathy (PML) lesions in the cerebrum and cerebellum. Active lesions showed marked perivascular lymphocytic cuffing. Papovaviruses were identified ultrastructurally in both oligodendrocytes and astrocytes. Multiple malignant astrocytomas were documented, originating from PML lesions. No viruses could be demonstrated in neoplastic astrocytes. An immune-deficient state was not revealed clinically or at postmortem examination.