Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism
Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism
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DOI：
10.1021/ol049852k
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发表时间：
2004-03-18
期刊：
影响因子：
5.2
通讯作者：
Clardy, J
中科院分区：
文献类型：
--
作者：
Stierle, DB;Stierle, AA;Clardy, J
从生长在蒙大拿州巴特伯克利坑湖的青霉属中分离出两个新的杂合聚酮萜类代谢物。通过光谱分析推导了它们的结构，并通过单晶x射线分析证实了它们的结构。两种化合物均抑制基质金属蛋白酶-3和caspase-1，伯克利二酮在NCI的人细胞系抗肿瘤筛选中显示出对非小细胞肺癌的活性。
Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen.