Id: a target of BMP signaling.
Id: a target of BMP signaling.
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DOI：
10.1126/stke.2002.151.pe40
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发表时间：
2002-09-24
期刊：
影响因子：
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通讯作者：
Miyazawa, Keiji
中科院分区：
文献类型：
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作者：
Miyazono, Kohei;Miyazawa, Keiji
转化生长因子- β (tgf - β)超家族的细胞因子通过激活受体调节的Smads （R-Smads）来传递信号。不同的R-Smads或R-Smads的组合被tgf - β、激活素或骨形态发生蛋白（BMPs）激活。被bmp激活的R-Smads诱导Id蛋白的表达，Id蛋白通过抑制碱性螺旋-环-螺旋转录因子的功能，起到抑制细胞分化和刺激细胞生长的作用。在内皮细胞中，tgf - β与两种不同的I型受体丝氨酸-苏氨酸激酶ALK-5和ALK-1结合；后者激活与BMP相同的R-Smads，并诱导合成Id（分化抑制剂或DNA结合抑制剂）蛋白。越来越多的证据表明，Id蛋白可能在血管生成、神经发生和骨生成中发挥重要作用，并作为调节bmp和tgf - β诱导的生物反应的关键分子。
Cytokines of the transforming growth factor-beta (TGF-beta) superfamily transduce their signals by activating receptor-regulated Smads (R-Smads). Distinct R-Smads or combinations of R-Smads are activated by TGF-beta, activin, or bone morphogenetic proteins (BMPs). R-Smads activated by BMPs induce expression of Id proteins, which act as inhibitors of differentiation and stimulators of cell growth by inhibiting the function of basic helix-loop-helix transcription factors. In endothelial cells, TGF-beta binds to two distinct type I receptor serine-threonine kinases, ALK-5 and ALK-1; the latter activates the same R-Smads that are activated by BMP and induces synthesis of Id (inhibitor of differentiation or inhibitor of DNA binding) proteins. Growing evidence suggests that Id proteins may play crucial roles in angiogenesis, neurogenesis, and osteogenesis and act as key molecules in regulating biological responses induced by BMPs and TGF-beta.