Conditional survival in gastric cancer: a SEER database analysis
Conditional survival in gastric cancer: a SEER database analysis
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DOI：
10.1007/s10120-007-0424-9
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发表时间：
2007-09-01
期刊：
影响因子：
7.4
通讯作者：
Thomas, Charles R., Jr.
中科院分区：
文献类型：
--
作者：
Wang, Samuel J.;Emery, Rachel;Thomas, Charles R., Jr.
背景胃癌的生存率通常是从诊断时起的生存率。对于诊断后已存活1年或1年以上的患者，条件生存率是一个更相关的预后指标。使用美国国家癌症研究所的监测、流行病学和最终结果（SEER 17）数据库，我们分析了1988年至1998年诊断的20018例胃癌患者的数据。使用生命表法，我们计算了5年相对条件生存率，按总结分期、年龄、性别和种族分组，对于诊断后已存活5年的患者。相对条件生存率随着时间的推移，提高了所有组的胃癌患者谁生存一段时间后诊断。晚期疾病患者的条件生存率提高最多。总体而言，雌性的存活率高于雄性。当按种族分组时，与其他种族类别相比，亚洲人的生存率继续提高，即使在诊断后5年。对于诊断后存活一段时间的胃癌患者，晚期疾病患者和65岁以下患者的条件生存率增加最多。对于诊断后存活一段时间的胃癌患者，条件生存期比诊断时的生存期能提供更多相关的预后信息。
Background. Gastric cancer survival is typically reported in terms of survival from the time of diagnosis. Conditional survival is a more relevant measure of prognosis for patients who have already survived 1 or more years since diagnosis.Methods. Using the Surveillance, Epidemiology, and End Results (SEER 17) database from the National Cancer Institute, we analyzed data from 20018 gastric cancer patients diagnosed between 1988 and 1998. Using the life-table method, we computed 5-year relative conditional survival, grouped by summary stage, age, sex, and ethnicity, for patients who had already survived up to 5 years from diagnosis.Results. Relative conditional survival improves over time for all groups of gastric cancer patients who survive a period of time after diagnosis. The largest gains in conditional survival were seen in patients with advanced stage disease. In general, females showed better survival than males. When grouped by ethnicity, Asians continued to have improved survival compared to other ethnic categories, even at 5 years out from diagnosis.Conclusion. For gastric cancer patients who survive a period of time after diagnosis, the largest increases in conditional survival are seen for patients with advanced stage disease and for those less than 65 years old. Conditional survival can provide more relevant prognostic information than survival from the time of diagnosis for gastric cancer patients who survive a period of time after diagnosis.