The involvement of the anterior cingulate cortex in remote contextual fear memory
The involvement of the anterior cingulate cortex in remote contextual fear memory
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DOI：
10.1126/science.1094804
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发表时间：
2004-05-07
期刊：
影响因子：
56.9
通讯作者：
Silva, AJ
中科院分区：
文献类型：
--
作者：
Frankland, PW;Bontempi, B;Silva, AJ
虽然最初记忆加工所需的分子、细胞和系统机制已经被深入研究，但永久记忆存储的基础仍然是难以捉摸的。我们目前的神经解剖学，药理学和遗传学的结果表明，前扣带皮层起着关键作用，在远程记忆的上下文恐惧条件反射。活动依赖性基因的成像显示，前扣带被远程记忆激活，这种激活受到阻断远程记忆的无效α-CaMKII突变的损害。因此，在正常小鼠中，这种结构的可逆失活破坏了远程记忆，而不影响最近的记忆。
Although the molecular, cellular, and systems mechanisms required for initial memory processing have been intensively investigated, those underlying permanent memory storage remain elusive. We present neuroanatomical, pharmacological, and genetic results demonstrating that the anterior cingulate cortex plays a critical role in remote memory for contextual fear conditioning. Imaging of activity-dependent genes shows that the anterior cingulate is activated by remote memory and that this activation is impaired by a null alpha-CaMKII mutation that blocks remote memory. Accordingly, reversible inactivation of this structure in normal mice disrupts remote memory without affecting recent memory.