Viagra for your synapses: Enhancement of hippocampal long-term potentiation by activation of beta-adrenergic receptors.
Viagra for your synapses: Enhancement of hippocampal long-term potentiation by activation of beta-adrenergic receptors.
复制标题
DOI：
10.1016/j.cellsig.2009.12.004
复制
发表时间：
2010-05
影响因子：
4.8
通讯作者：
Nguyen PV
中科院分区：
文献类型：
--
作者：
O'Dell TJ;Connor SA;Gelinas JN;Nguyen PV
β-肾上腺素能受体（β-AR）对哺乳动物大脑中持久的突触可塑性和长期记忆储存具有重要调节作用。突触可塑性被广泛认为在细胞水平上介导记忆储存。长时程增强（LTP）是一种与记忆储存有关的突触可塑性。β-ARs的激活可以增强LTP，促进长期记忆的储存。有趣的是，许多对LTP的β-肾上腺素能调节至关重要的分子信号传导途径反映了记忆持久性所需的分子信号传导途径。本文综述了信号级联和翻译调控在β-AR调控啮齿动物海马LTP表达中的作用。这些包括环AMP/蛋白激酶-A（cAMP-PKA）和细胞外信号调节的蛋白激酶级联，这是已知将递质受体与翻译调节联系起来的两个关键途径。最后讨论了未来的研究方向，重点是确定信号复合物（如PSD-95）和β-AR受体在控制β-AR调节LTP中的作用。
Beta-adrenergic receptors (β-ARs) critically modulate long-lasting synaptic plasticity and long-term memory storage in the mammalian brain. Synaptic plasticity is widely believed to mediate memory storage at the cellular level. Long-term potentiation (LTP) is one type of synaptic plasticity that has been linked to memory storage. Activation of β-ARs can enhance LTP and facilitate long-term memory storage. Interestingly, many of the molecular signaling pathways that are critical for β-adrenergic modulation of LTP mirror those required for the persistence of memory. In this article, we review the roles of signaling cascades and translation regulation in enabling β-ARs to control expression of long-lasting LTP in the rodent hippocampus. These include the cyclic-AMP/protein kinase-A (cAMP-PKA) and extracellular signal-regulated protein kinase cascades, two key pathways known to link transmitter receptors with translation regulation. Future research directions are discussed, with emphasis on defining the roles of signaling complexes (e.g. PSD-95) and glutamatergic receptors in controlling the efficacy of β-AR modulation of LTP.
登录
查看更多内容
影响因子：
5.3
作者：
Banko, JL;Poulin, F;Klann, E
通讯作者：
Klann, E
影响因子：
4.1
作者：
Bolger, Graeme B.;Baillie, George S.;Houslay, Miles D.
通讯作者：
Houslay, Miles D.
影响因子：
5.5
作者：
BLISS, TVP;LOMO, T
通讯作者：
LOMO, T
DOI：
10.1073/pnas.95.25.15020
发表时间：
1998-12-08
影响因子：
11.1
作者：
Barad, M;Bourtchouladze, R;Kandel, E
通讯作者：
Kandel, E
影响因子：
16.2
作者：
Bloodgood, Brenda L.;Sabatini, Bernardo L.
通讯作者：
Sabatini, Bernardo L.