Pattern of retinal projections in the California ground squirrel (Spermophilus beecheyi): anterograde tracing study using cholera toxin.
Pattern of retinal projections in the California ground squirrel (Spermophilus beecheyi): anterograde tracing study using cholera toxin.
复制标题
加州地松鼠（Spermophilus beecheyi）的视网膜投影模式：使用霍乱毒素的顺行追踪研究。
DOI：
10.1002/cne.10764
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Karten,HarveyJ
中科院分区：
文献类型：
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作者：
Major,DanielE;Rodman,HillaryR;Libedinsky,Camilo;Karten,HarveyJ
在玻璃体内注射霍乱毒素B亚单位后，绘制了加州黄鼠（Spermophilus beecheyi）的离视网膜途径。目前的研究结果与其他哺乳动物的研究结果一致，并提供了与视觉系统的组织和进化相关的新细节。所有retinorecipient核接受双边输入，对侧优势。视交叉上核神经支配较重，下丘脑其他区域有稀疏终末。除了间质核、内侧核、外侧核和背侧终核外，副视束的少数纤维可以进入腹外侧膝状体和视束核，尽管这种神经支配可能不是来自支配副视核的相同神经节细胞。视网膜终末位于膝状体间小叶和腹侧膝状体的“背帽”中。视网膜纤维从背帽向前背侧丘脑的吻侧延伸，证实了树鼩和猴子中描述的投射。背侧外侧膝状体的视网膜终止模式揭示了交替的同侧和对侧输入的hexilaminate组织。终端形态的变化表明，亚层从不同的神经节细胞类型的输入和层状比较，可以与灵长类动物。最后，终端模式在上级丘揭示了一个密集的，高度有序的柱状组织支持功能特性的顶盖感受野。地松鼠的所有视觉结构都很大且分化良好，这使得松鼠的视觉系统成为一种可用于与其他昼行性脊椎动物进行视觉处理比较的啮齿动物模型。J. Comp.神经元463：317-340，2003.© 2003 Wiley利斯公司
The retinofugal pathways in the California ground squirrel,Spermophilus beecheyi, were mapped after intravitreal injections of cholera toxin B‐subunit. The results of the current study are consistent with work in other mammals and provide new details relevant to the organization and evolution of the visual system. All retinorecipient nuclei received bilateral input, with a contralateral predominance. The suprachiasmatic nucleus is heavily innervated, and sparse terminals were noted in other hypothalamic areas. In addition to the interstitial, medial, lateral, and dorsal terminal nuclei, a few fibers of the accessory optic tract may enter the ventral lateral geniculate and the nucleus of the optic tract, though this innervation may not derive from the same ganglion cells innervating the accessory optic nuclei. Retinal terminals are found in the intergeniculate leaflet and the “dorsal cap” of the ventral lateral geniculate. Retinal fibers pass rostrally from the dorsal cap toward the anterodorsal thalamus, confirming a projection described in the tree shrew and monkeys. Retinal termination patterns in the dorsal lateral geniculate reveal a hexilaminate organization of alternating ipsilateral and contralateral input. Variations in terminal morphology suggest that sublayers receive input from distinct ganglion cell types and that laminar comparisons can be made with primates. Finally, terminal patterns in the superior colliculus reveal a dense, highly ordered columnar organization supporting functional properties of tectal receptive fields. All the visual structures in the ground squirrel are large and well differentiated, making the sciurid visual system an accessible rodent model for comparing visual processing with that in other diurnal vertebrates. J. Comp. Neurol. 463:317–340, 2003. © 2003 Wiley‐Liss, Inc.