Functional and effective connectivity in an fMRI study of an auditory-related task
Functional and effective connectivity in an fMRI study of an auditory-related task
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DOI：
10.1111/j.1460-9568.2006.04773.x
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发表时间：
2006-05-01
影响因子：
3.4
通讯作者：
Fonlupt, Pierre
中科院分区：
文献类型：
--
作者：
Caclin, Anne;Fonlupt, Pierre
这项研究调查了在听觉目标导向任务中功能连接的大脑区域组。我们使用的范例包括静止状态条件和活动状态，其中包括主动聆听人类行走的脚步声。使用功能磁共振成像测量区域大脑活动，并使用主成分分析和结构方程模型分析参与任务的大脑区域的活动调整值。第一组连接区域包括位于赫施尔回、颞平面、后上颞沟（在所谓的“社会认知”区域）和顶叶的区域。该网络可能负责听觉信号的感知整合。第二组包含额叶区域，与注意力控制有关。背外侧和内侧前额叶皮层具有相互的负面影响，这与视觉目标导向任务中描述的类似[T. Chaminade & P. Fonlupt (2003) 欧洲。神经科学杂志，18, 675 - 679.]。此外，背外侧前额叶皮层（DLPFC）在任务过程中对听觉区域产生积极影响，同时对视觉区域产生强烈的负面影响。这些结果表明：（i）在目标导向任务期间，额叶皮层内侧和外侧部分之间的负面影响不依赖于输入模态（视觉或听觉），并且（ii）DLPFC 激活相关感觉模态通路并抑制不相关感觉模态通路。
This study investigates the sets of brain areas that are functionally connected during an auditory goal-directed task. We used a paradigm including a resting state condition and an active condition, which consisted in active listening to the footsteps of walking humans. The regional brain activity was measured using fMRI and the adjusted values of activity in brain regions involved in the task were analysed using both principal component analysis and structural equation modelling. A first set of connected areas includes regions located in Heschl's gyrus, planum temporale, posterior superior temporal sulcus (in the so-called `social cognition' area), and parietal lobe. This network could be responsible for the perceptual integration of the auditory signal. A second set encompassing frontal regions is related to attentional control. Dorsolateral- and medial-prefrontal cortex have mutual negative influences which are similar to those described during a visual goal-directed task [T. Chaminade & P. Fonlupt (2003) Eur. J. Neurosci., 18, 675 - 679.]. Moreover, the dorsolateral prefrontal cortex (DLPFC) exerts a positive influence on the auditory areas during the task, as well as a strong negative influence on the visual areas. These results show that: (i) the negative influence between the medial and lateral parts of the frontal cortex during a goal-directed task is not dependent on the input modality (visual or auditory), and (ii) the DLPFC activates the pathway of the relevant sensory modality and inhibits the nonrelevant sensory modality pathway.