Improvement in interstitial cystitis symptom scores during treatment with oral L-arginine
Improvement in interstitial cystitis symptom scores during treatment with oral L-arginine
复制标题
DOI：
10.1016/s0022-5347(01)64297-6
复制
发表时间：
1997-09-01
影响因子：
6.6
通讯作者：
Weiss, RM
中科院分区：
文献类型：
--
作者：
Smith, SD;Wheeler, MA;Weiss, RM
目的：间质性膀胱炎患者尿一氧化氮合酶活性降低。由于一氧化氮可能是一个重要的决定因素的症状和免疫反应与间质性膀胱炎，这种疾病的患者进行了治疗与口服L-精氨酸，底物一氧化氮synthes.Materials和方法：10例患者服用1.5克。每日口服L-精氨酸，持续6个月。间质性膀胱炎的症状进行了调查之前和期间的B-month trial.Results：口服L-精氨酸治疗导致排尿不适，下腹部疼痛和阴道/尿道疼痛显着减少。在白天和夜间的排尿频率也显着reduced.Conclusions：这项自我对照研究提供的证据表明，长期口服L-精氨酸改善间质性膀胱炎相关症状。
Purpose: Urinary nitric oxide synthase activity is decreased in patients with interstitial cystitis. Since nitric oxide may be an important determinant of the symptoms and immunological responses associated with interstitial cystitis, patients with this disease were treated with oral L-arginine, the substrate for nitric oxide synthase.Materials and Methods: Ten patients took 1.5 gm. L-arginine orally daily for 6 months. Interstitial cystitis symptoms were surveyed before and during the B-month trial.Results: Oral L-arginine treatment resulted in a significant decrease in urinary voiding discomfort, lower abdominal pain and vaginal/urethral pain. Urinary frequency during the day and night also significantly decreased.Conclusions: This self-controlled study provides evidence that long-term oral L-arginine improves interstitial cystitis related symptoms.