Zooprophylaxis, artefact or reality? A paired-cohort study of the effect of passive zooprophylaxis on malaria in The Gambia
Zooprophylaxis, artefact or reality? A paired-cohort study of the effect of passive zooprophylaxis on malaria in The Gambia
复制标题
DOI：
10.1016/s0035-9203(02)90320-2
复制
发表时间：
2002-11-01
影响因子：
2.2
通讯作者：
Lindsay, SW
中科院分区：
文献类型：
--
作者：
Bogh, C;Clarke, SE;Lindsay, SW
自1982年以来，世界卫生组织一直建议使用牛进行动物预防，以此作为对抗疟疾的保护措施。然而，人们对这一做法表示关切，因为一些研究表明，牛的存在反而可能增加疟疾的流行。这项研究旨在调查在西非冈比亚一个中度季节性传播地区被动动物预防对疟疾的影响。这项研究基于204名7岁儿童的配对队列，他们睡在牛身上20米或50米，调查于1997年10月14日至12月2日进行。昆虫学调查表明，牛的存在并没有改变附近房屋中疟疾传播的风险。两组间恶性疟原虫患病率亦无显著差异。虽然牛的存在似乎对高度寄生虫病具有保护作用，但牛也与儿童家庭的更多财富有关。条件Logistic回归分析表明，在有牛的人群中，高寄生虫血症的风险降低是与牛主的总体财富较高有关的假象。我们的结论是，在与冈比亚类似的环境中，动物预防并不是有效的疟疾干预方法。
The World Health Organization has recommended the use of cattle for zooprophylaxis as a protective measure against malaria since 1982. However, concern has been raised about this practice, since some studies have shown that the presence of cattle may instead increase malaria prevalence. This study was designed to investigate the effect of passive zooprophylaxis on malaria in an area of moderate seasonal transmission in The Gambia, West Africa. The study was based on a paired-cohort of 204 children aged < 7 years, sleeping < 20 m or > 50 m from cattle, and surveys were done from 14 October to 2 December 1997. Entomological investigations showed that the presence of cattle did not alter the risk of malaria transmission in nearby houses. There was also no significant difference in the prevalence of Plasmodium falciparum between the 2 groups. Although the presence of cattle appeared to be protective against high parasitaemia, cattle were also associated with greater wealth of the children's families. Conditional logistic regression analysis showed that the decreased risk of high parasitaemia in the group with cattle present was an artefact associated with the higher general wealth of the cattle owners. We concluded that zooprophylaxis is not an effective intervention method against malaria in settings similar to The Gambia.