QUANTITATIVE PHARMACOLOGICAL CHARACTERIZATION OF BETA-RECEPTORS AND 2 TYPES OF ALPHA-RECEPTORS MEDIATING SYMPATHOMIMETIC SMOOTH-MUSCLE RESPONSE IN THE HUMAN FALLOPIAN-TUBE AT VARIOUS CYCLIC STAGES
QUANTITATIVE PHARMACOLOGICAL CHARACTERIZATION OF BETA-RECEPTORS AND 2 TYPES OF ALPHA-RECEPTORS MEDIATING SYMPATHOMIMETIC SMOOTH-MUSCLE RESPONSE IN THE HUMAN FALLOPIAN-TUBE AT VARIOUS CYCLIC STAGES
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DOI：
10.1111/j.1748-1716.1982.tb07005.x
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
WALLES, B
中科院分区：
文献类型：
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作者：
HELM, G;OWMAN, C;WALLES, B
The Kd for adrenoceptor-antagonist complexes (KB) were determined in vitro in circular and longitudinal smooth musculature from the ampullary and isthmic regions of the human Fallopian tube. High extracellular K concentrations were used to eliminate the spontaneous contractile activity. Neuronal and extraneuronal amine uptake mechanisms were blocked. The parallel shift of the log dose-response curves was secured in Arunlakshana-Schild plots. KB for the .beta.-receptor, mediating sympathomimetic relaxation, were determined during .alpha.-receptor blockade: the values for propranolol were the same (approximately 10-6 M) in all preparations and at all cyclic stages, as determined from plasma estradiol and progesterone levels. KB for the complex between the .alpha.-receptor (mediating contraction) and phentolamine were determined during .beta.-receptor blockade. The values were the same in all types of smooth musculature, but varied with cyclic stage: they were around 7 .times. 10-8 M when plasma estradiol and progesterone were both minimum, and around 2 .times. 10-7 M when these steroid levels were moderate to high, suggesting that the properties of the contractile receptors of the human Fallopian tube are modified during the menstrual cycle.
