A comparison of medication side effect reports by panic disorder patients with and without concomitant cognitive behavior therapy.
A comparison of medication side effect reports by panic disorder patients with and without concomitant cognitive behavior therapy.
复制标题
恐慌症患者接受和不接受认知行为治疗的药物副作用报告的比较。
DOI：
10.1176/ajp.2007.164.2.273
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Woods,Scott
中科院分区：
文献类型：
--
作者：
Marcus,SueM;Gorman,Jack;Shear,MKatherine;Lewin,David;Martinez,Jose;Ray,Susan;Goetz,Raymond;Mosovich,Serge;Gorman,Lauren;Barlow,David;Woods,Scott
作者评估了是否增加认知行为疗法（CBT），以丙咪嗪惊恐障碍患者的副作用和辍学的严重程度，从副作用.MethodData进行了分析，为172例惊恐障碍患者被随机分配到接受丙咪嗪单独，丙咪嗪加CBT，或安慰剂。混合效应模型被用来评估治疗组之间的纵向差异方面的副作用负担和辍学率在急性，维持和后续阶段的treatment.ResultsPatients治疗丙咪嗪加CBT经历了较轻的疲劳/虚弱，口干，与单用丙咪嗪治疗的患者相比，CBT的加入可降低因副作用而导致的脱落率。与单独使用丙咪嗪治疗相比，使用丙咪嗪的药物治疗与较不严重的副作用和较少的由于感知到的副作用而脱落相关。
ObjectiveThe authors assessed whether adding cognitive behavior therapy (CBT) to imipramine for patients with panic disorder decreased the severity of side effects and dropouts from side effects.MethodData were analyzed for 172 panic disorder patients who were randomly assigned to receive imipramine alone, imipramine plus CBT, or placebo. Mixed-effects models were used to assess longitudinal differences among the treatment groups with respect to side effect burden and dropout rates during the acute, maintenance, and follow-up phases of treatment.ResultsPatients treated with imipramine plus CBT experienced less severe fatigue/weakness, dry mouth, and sweating and had a lower rate of dropout due to side effects compared with those treated with imipramine only.ConclusionsThe addition of CBT to medication treatment with imipramine was associated with less severe side effects and fewer dropouts due to perceived side effects than treatment with imipramine alone.