Neurodevelopmental theory of depression
Neurodevelopmental theory of depression
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DOI：
10.1016/j.pnpbp.2017.05.023
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发表时间：
2018-01-03
影响因子：
5.6
通讯作者：
Talarowska, Monika
中科院分区：
文献类型：
--
作者：
Galecki, Piotr;Talarowska, Monika
近年来在精神病学领域进行的研究的目的是制定一个一致的理论，将详尽地解释抑郁症的病因。到目前为止，生物化学，遗传，解剖学和环境因素，这可能会发挥作用的发生的第一个症状的抑郁症，一直在寻找。本文的作者提出了一种理论，将前面提到的元素组合成一个整体，并将它们彼此联系起来。我们称我们的理论为“神经发育”，以强调人类生命的早期阶段（包括产前阶段）对抑郁症发生的重要性和影响。我们将试图找到一个答案，为什么这个时候在一个人的生活是如此重要，什么样的生物机制被激活，我们以后的功能的哪些方面受到影响。
The aim of research studies in the field of psychiatry conducted in recent years is to formulate a consistent theory that would exhaustively explain the aetiology of depression. So far, biochemical, genetic, anatomical and environmental factors, which may play a role in the occurrence of the first symptoms of depressive disorders, have been sought. The authors of this paper present a theory that combines the previously mentioned elements into one whole and links them to one another. We have called our theory "neurodevelopmental" to underline the importance and impact of earlier stages of human life, including the prenatal period, on the occurrence of depressive disorders. We will make an attempt to find an answer to why this time in the life of a human being is so important, what kind of biological mechanisms are activated then, and what aspects of our later functioning are affected by them.