Is Creutzfeldt-Jakob disease transmitted in blood?
Is Creutzfeldt-Jakob disease transmitted in blood?
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DOI：
10.3201/eid0302.970208
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发表时间：
1997-04
影响因子：
11.8
通讯作者：
ElSaadany S
中科院分区：
文献类型：
--
作者：
Ricketts MN;Cashman NR;Stratton EE;ElSaadany S
克雅氏病（Creutzfeldt-Jakob disease，CJD）自20世纪60年代中期以来一直被认为具有传染性，但其通过输血或血液制品的传播性仍存在争议。病原体的新的不确定性和对标准去污的抗性，缺乏筛查试验，以及认识到即使是罕见的传播病例也可能是不可接受的，导致全球范围内对影响血液制品生产从血液采集到输血的各个方面的政策和程序进行了修订。我们回顾了目前CJD通过血液传播的证据。
Creutzfeldt-Jakob disease (CJD) has been considered infectious since the mid-1960s, but its transmissibility through the transfusion of blood or blood products is controversial. The causative agent's novel undefined nature and resistance to standard decontamination, the absence of a screening test, and the recognition that even rare cases of transmission may be unacceptable have led to the revision of policies and procedures worldwide affecting all facets of blood product manufacturing from blood collection to transfusion. We reviewed current evidence that CJD is transmitted through blood.