Effects of a maternal psychosocial intervention on hair derived biomarkers of HPA axis function in mothers and children in rural Pakistan.
Effects of a maternal psychosocial intervention on hair derived biomarkers of HPA axis function in mothers and children in rural Pakistan.
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DOI：
10.1016/j.ssmmh.2022.100082
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发表时间：
2022-12-01
期刊：
影响因子：
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通讯作者：
Maselko, Joanna
中科院分区：
文献类型：
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作者：
Baranov, Victoria;Frost, Allison;Maselko, Joanna
目的：下丘脑-垂体-肾上腺(HPA)轴的紊乱被认为是精神病理学中的关键神经内分泌机制，并可能产生代际影响。毛发衍生的HPA激素提供了一种长期HPA轴活动的衡量标准，这可能有助于评估母婴健康。基于巴基斯坦围产期抑郁干预的社区随机对照试验，我们检验了对母亲和婴儿HPA轴活动的干预效果。方法：使用毛发来源的皮质醇、可的松和脱氢表雄酮(DHEA)评估HPA轴活动。头发样本来自产后一年的抑郁妇女，随机分为认知行为干预组(n=35对)或强化日常护理组(n=37对)，以及孕期抑郁症筛查阴性的对照样本(n=35对)。结果：与EUC组相比，干预组的母亲皮质醇水平降低了38%(p=0.01)，母亲皮质醇水平降低了45%(p<；0.01)。干预组孕妇的DHEA水平比EUC组高29%(p=0.02)。代际干预效果显示，婴儿的DHEA水平高出43%(p=0.03)。结论：围产期抑郁干预对母亲和儿童HPA轴活动均有影响，为治疗母亲抑郁可能影响代际生理应激系统功能提供了证据。此外，利用毛发衍生的HPA轴活动的生物标志物是干预对神经内分泌系统影响的潜在有用的临床指标。
Objective: Disruptions in the hypothalamic-pituitary-adrenal (HPA) axis are thought to be key neuroendocrine mechanisms involved in psychopathology and may have intergenerational impacts. Hair-derived HPA hormones offer a measure of long-term HPA axis activity that may be useful in assessing maternal and infant health. Building on a community-based randomized control trial of a perinatal depression intervention in Pakistan, we examine intervention effects on HPA axis activity in a subsample of mothers and infants.Methods: HPA axis activity was assessed using hair-derived cortisol, cortisone, and dehydroepiandosterone (DHEA). Hair samples were collected from mother-child dyads at one year postpartum from prenatally depressed women randomized to a cognitive-behavioral intervention (n = 35 dyads) or to enhanced usual care (n = 37 dyads), and from a comparison sample of women who screened negative for depression in pregnancy (n = 35 dyads).Results: The intervention group had 38 percent (p=0.01) lower maternal cortisol levels and 45 percent (p < 0.01) lower maternal cortisone compared to the EUC group. Maternal DHEA levels were higher among women in the intervention group compared to the EUC group by 29 percent (p = 0.02). Intergenerational intervention effects show higher DHEA levels in infants by 43% (p = 0.03). Infant cortisol and cortisone did not differ across groups.Conclusions: Results suggest that the perinatal depression intervention has effects on HPA axis activity in both mothers and children, providing evidence that treating maternal depression may impact physiological stress system functioning intergenerationally. In addition, utilizing hair-derived biomarkers of HPA-axis activity is a potentially useful clinical indicator of intervention impacts on the neuroendocrine system.