Learning of anticipatory responses in single neurons of the human medial temporal lobe
Learning of anticipatory responses in single neurons of the human medial temporal lobe
复制标题
DOI：
10.1038/ncomms9556
复制
发表时间：
2015-10-01
影响因子：
16.6
通讯作者：
Roelfsema, Pieter R.
中科院分区：
文献类型：
--
作者：
Reddy, Leila;Poncet, Marlene;Roelfsema, Pieter R.
人类大脑中形成新的联系的神经过程还没有被很好地理解。在这里，人类参与者在大脑中植入深度电极，学习以有序、可预测的序列呈现的图像之间的任意关联。在学习过程中，我们记录了内侧颞叶(MTL)神经元对序列中至少一张图片(首选刺激)的反应。我们报告说，作为学习的结果，单个MTL神经元表现出不对称的活动转移，并在预期它们喜欢的刺激的序列中更早地开始放电。在经历了11次刺激序列之后，这些效应在学习中出现得相对较早。当受试者在报告序列中的下一项时变得更快时，预期的神经元反应就会出现。这些结果表明，灵活的表征可以支持学习序列中刺激之间的新联系，在人类MTL的单个神经元中。
Neuronal processes underlying the formation of new associations in the human brain are not yet well understood. Here human participants, implanted with depth electrodes in the brain, learned arbitrary associations between images presented in an ordered, predictable sequence. During learning we recorded from medial temporal lobe (MTL) neurons that responded to at least one of the pictures in the sequence (the preferred stimulus). We report that as a result of learning, single MTL neurons show asymmetric shifts in activity and start firing earlier in the sequence in anticipation of their preferred stimulus. These effects appear relatively early in learning, after only 11 exposures to the stimulus sequence. The anticipatory neuronal responses emerge while the subjects became faster in reporting the next item in the sequence. These results demonstrate flexible representations that could support learning of new associations between stimuli in a sequence, in single neurons in the human MTL.