Association Between Polymorphisms in CMTM Family Genes and Hepatocellular Carcinoma in Guangxi of China
Association Between Polymorphisms in CMTM Family Genes and Hepatocellular Carcinoma in Guangxi of China
复制标题
CMTM家族基因多态性与广西肝癌的相关性。
DOI：
10.1089/dna.2018.4274
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发表时间：
2018-07-10
影响因子：
3.1
通讯作者：
Tan, Shengkui
中科院分区：
文献类型：
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作者：
Bei, Chunhua;Tan, Chao;Tan, Shengkui
基因多态性可能影响其表达并改变个体对癌症的易感性。在这项研究中，我们调查CMTM家族基因多态性与中国南方人群肝细胞癌（HCC）之间的关联。使用Sequenom MassARRAY平台对315例HCC患者和315例无癌对照进行CMTM家族基因中10个选定的单核苷酸多态性（SNP）基因分型，并评估选定SNP与HCC风险的相关性。发现rs 164207 AA基因型个体发生肝癌的危险性显著高于CC基因型个体（校正OR = 2.794，95%CI = 1.143-6.828）。rs3811178 GG基因型个体与AA基因型个体相比，HCC风险增加（校正OR = 2.578，95%CI = 1.114-5.969）。此外，当这些基因座的风险基因型组合时，HCC的风险也显著增加，即，rs164207 AA，CA和rs3811178 GG，GA。与低危组（0种危险基因型）相比，高危组（2种危险基因型）发生肝癌的危险性显著增加（校正OR = 3.339，95%CI = 1.119-9.964，p = 0.031）。我们的研究结果表明，CMTM 5基因rs3811178和CMTM 6基因rs 164207多态性可能与中国南方人群肝癌的遗传易感性有关。需要更大样本量的进一步精心设计的研究来证实我们的发现。
Polymorphisms in genes may affect its expression and alter individual susceptibility to cancer. In this study, we investigate associations between CMTM family gene polymorphisms and hepatocellular carcinoma (HCC) in a southern Chinese population. Ten selected single-nucleotide polymorphisms (SNPs) in CMTM family genes were genotyped in 315 HCC patients and 315 cancer-free controls using Sequenom MassARRAY platform and the associations of the selected SNPs with HCC risk were evaluated. We found individuals with the rs164207 AA genotypes had a significantly increased risk of HCC than those with CC genotypes (adjusted OR = 2.794, 95% CI = 1.143-6.828). Also, individuals with the rs3811178 GG genotypes showed a significant association with increased risk of HCC when compared with the AA genotypes (adjusted OR = 2.578, 95% CI = 1.114-5.969). Furthermore, there was also a significantly increased risk of HCC when combined risk genotypes of these loci, i.e., rs164207 AA, CA and rs3811178 GG, GA. Compared with the low-risk group (0 risk genotypes), the high-risk group (2 risk genotypes) was at significantly increased risk of HCC (adjusted OR = 3.339, 95% CI = 1.119-9.964, p = 0.031). Our results suggest that polymorphisms of rs3811178 in CMTM5 and rs164207 in CMTM6 might contribute to the genetic susceptibility of HCC in the southern Chinese population. Further well-designed studies with larger sample sizes are needed to confirm our findings.