Association between graft source and response to live-attenuated vaccination in pediatric hematopoietic stem cell transplantation recipients: a single-center retrospective study.
Association between graft source and response to live-attenuated vaccination in pediatric hematopoietic stem cell transplantation recipients: a single-center retrospective study.
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移植物来源与儿童造血干细胞移植受者对减毒活疫苗反应之间的关联：一项单中心回顾性研究。
DOI：
10.1038/s41409-020-0867-8
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Ito Y
中科院分区：
文献类型：
--
作者：
Suzuki T;Kawada JI;Nishikawa E;Torii Y;Horiba K;Takeuchi S;Okumura T;Muramatsu H;Takahashi Y;Ito Y
感染控制是造血干细胞移植（HSCT）后最重要的问题之一。移植受者发生疫苗可预防疾病（VPDs）的风险仍然存在；事实上，在这一人群中已经报道了几例致死性VPD[1,2]。移植前获得的免疫力，包括之前接种疫苗获得的免疫力，在移植后逐渐减弱[3-6]。据报道，大多数有自然感染史的患者血清仍呈阳性，而接种过疫苗的儿童通常在骨髓移植（BMT）后失去免疫力[4,5]。因此，造血干细胞移植受者，尤其是儿科患者，必须考虑在移植后再次接种疫苗。已经提出了几种HSCT后疫苗接种指南[3,7 - 9]。然而，关于造血干细胞移植后接种疫苗（特别是减毒活疫苗）的有效性和安全性的报道仍然有限。此外，没有研究比较BMT、脐带血移植（CBT）和自体外周血干细胞移植（PBSCT）之间的免疫或疫苗反应。
Infection control is one of the most important issues after hematopoietic stem cell transplantation (HSCT). The risk of vaccine-preventable diseases (VPDs) still exists for HSCT recipients; indeed, several cases of fatal VPD have been reported in this population [1, 2]. Immunity acquired before HSCT, including acquired immunity from previous vaccination, has been well described as diminishing after HSCT [3–6]. Most patients who have had a natural history of infection reportedly remain seropositive, while children who have been immunized commonly lose their immunity after bone marrow transplantation (BMT)[4, 5]. HSCT recipients, especially pediatric patients, must therefore be considered for revaccination after HSCT. Several guidelines for vaccination following HSCT have been proposed [3, 7–9]. However, reports on the efficacy and safety of vaccination (particularly live-attenuated vaccination) after HSCT remain limited. Moreover, no studies have compared immunity or vaccine response among BMT, umbilical cord blood transplantation (CBT), and autologous peripheral blood stem cell transplantation (PBSCT).