An output-null signature of inertial load in motor cortex.
An output-null signature of inertial load in motor cortex.
复制标题
运动皮层惯性负载的输出零特征。
DOI：
10.1101/2023.11.06.565869
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Sauerbrei,BrittonA
中科院分区：
文献类型：
--
作者：
Kirk,EricA;Hope,KeenanT;Sober,SamuelJ;Sauerbrei,BrittonA
协调运动需要神经系统在不同的条件下不断地补偿机械负荷的变化。对于伸手这样的自主运动，运动皮质是一个关键的中枢，它会产生移动肢体和抵消负荷的命令。当脊椎模式生成器对有节奏的运动进行排序时，皮质如何对负荷补偿做出贡献？在这里，我们通过在自由运动的小鼠身上操纵前肢的质量来解决这个问题。虽然负荷会导致运动输出的变化，对运动皮质的失活具有很强的抵抗力，但它也会导致大脑皮层动力学的深刻变化。这种变化受小脑扰动的影响最小，明显大于脊髓运动神经元群体中的负荷反应。当自由运动必须与持续的脊椎产生的节奏相结合时，这种潜在的表征可能使运动皮质产生适当的命令。
Coordinated movement requires the nervous system to continuously compensate for changes in mechanical load across different conditions. For voluntary movements like reaching, the motor cortex is a critical hub that generates commands to move the limbs and counteract loads. How does cortex contribute to load compensation when rhythmic movements are sequenced by a spinal pattern generator? Here, we address this question by manipulating the mass of the forelimb in unrestrained mice during locomotion. While load produces changes in motor output that are robust to inactivation of motor cortex, it also induces a profound shift in cortical dynamics. This shift is minimally affected by cerebellar perturbation and significantly larger than the load response in the spinal motoneuron population. This latent representation may enable motor cortex to generate appropriate commands when a voluntary movement must be integrated with an ongoing, spinally-generated rhythm.