Feeding the low-birth-weight infant: II. Effects of taurine and cholesterol supplementation on amino acids and cholesterol.
Feeding the low-birth-weight infant: II. Effects of taurine and cholesterol supplementation on amino acids and cholesterol.
复制标题
喂养低出生体重婴儿：II．
作者：
D. Rassin;G. Gaull;A. Järvenpää;N. Räihä
未添加牛磺酸的配方奶粉喂养的早产儿血浆和尿液中牛磺酸浓度始终低于母乳喂养或添加牛磺酸或牛磺酸加胆固醇的配方奶粉喂养的早产儿。这种配方食品的补充使血浆和尿液中的牛磺酸浓度恢复到母乳喂养的婴儿中观察到的水平。牛磺酸是唯一一种在未添加配方奶粉的婴儿中浓度低于母乳的氨基酸。其他酸性和中性氨基酸在配方奶粉喂养的婴儿中的浓度高于母乳喂养组，无论是在研究的最初几周（丝氨酸、谷氨酰胺、甘氨酸、丙氨酸、酪氨酸和蛋氨酸）还是在整个研究期间（苏氨酸、谷氨酸、瓜氨酸、缬氨酸、异亮氨酸、亮氨酸和苯丙氨酸）。补充牛磺酸和胆固醇的配方奶似乎对血浆和尿液中的氨基酸浓度没有任何影响，除了牛磺酸本身。血浆总胆固醇浓度下降，在第5至第12周出生后的生活在所有喂养组。然后，它恢复到出生后第一周和第三周在所有喂养组中发现的浓度，除了在喂养配方奶粉补充牛磺酸加胆固醇的婴儿中，其下降幅度更大。
Plasma and urine concentrations of taurine were consistently lower in preterm infants fed unsupplemented formula than those observed in the infants fed human milk or formulas supplemented with taurine alone or with taurine plus cholesterol. Such supplementation of formula restored plasma and urine concentrations of taurine to those observed in the infants fed human milk. Taurine was the only amino acid that was present at lower concentrations in the infants fed unsupplemented formula than in those fed human milk. The other acidic and neutral amino acids were present in higher concentrations in the formula-fed infants than in the group fed human milk either during the early weeks of the study (serine, glutamine, glycine, alanine, tyrosine, and methionine) or consistently higher during the entire study (threonine, glutamate, citrulline, valine, isoleucine, leucine, and phenylalanine). Supplementation of formula with taurine plus cholesterol did not appear to have any effect on the amino acid concentrations in the plasma and urine, other than that on taurine itself. Plasma total cholesterol concentration decreased during the fifth to the 12th postnatal weeks of life in all feeding groups. It then returned to the concentrations found during the first and third postnatal weeks in all feeding groups except in the infants fed formulas supplemented with taurine plus cholesterol which had a greater decrease.