Psychological impact of genetic testing for breast cancer susceptibility in women of Ashkenazi Jewish background: A prospective study
Psychological impact of genetic testing for breast cancer susceptibility in women of Ashkenazi Jewish background: A prospective study
复制标题
DOI：
10.1089/gte.2004.8.240
复制
发表时间：
2004-09-01
期刊：
影响因子：
--
通讯作者：
Tucker, K
中科院分区：
文献类型：
--
作者：
Andrews, L;Meiser, B;Tucker, K
在德系犹太人中，BRCA 1和BRCA 2基因的三个创始人突变的患病率超过2%，这一认识导致了对这个民族宗教群体的许多流行病学研究。为了确定将研究纳入临床实践的效果，对参加流行病学研究的妇女进行了心理影响研究。60名德系犹太背景的女性接受了创始人突变的基因检测，使用邮寄的自我管理问卷进行了评估，并对心理结果进行了验证。43名妇女当选后了解了选举结果，17名妇女拒绝这样做。选择了解其结果的妇女还在结果公布后7-10天、4个月和12个月接受了评估。选择了解结果的女性与选择不了解结果的女性相比，基线乳腺癌焦虑显著更高（z = -2.27; p = 0.023）。与基线相比，选择了解其结果的未受影响的女性在通知后4个月（z =-2.37，p = 0.018）和12个月（z =-3.06，p = 0.002）显示乳腺癌焦虑显著降低。对德系犹太妇女常见的突变进行基因检测，并公布结果，不会导致不良的心理后果。
The recognition that the prevalence of three founder mutations in the BRCA1 and BRCA2 genes is over 2% in Ashkenazi Jews has resulted in numerous epidemiological research studies of this ethno-religious group. To determine the effects of incorporating research into clinical practice, a psychological impact study of women participating in an epidemiological study was conducted. Sixty women of Ashkenazi Jewish background who underwent genetic testing for founder mutations were assessed using mailed, self-administered questionnaires with validated measures of psychological outcome. Forty-three women elected to learn their results and 17 women declined to do so. Women who elected to learn their results were also assessed 7-10 days, 4 months, and 12 months after results disclosure. Women who chose to learn their results had significantly higher baseline breast cancer anxiety, compared to those who elected not to learn their results (z = -2.27; p = 0.023). Unaffected women who elected to learn their results showed a significant decrease in breast cancer anxiety 4 months (z = -2.37, p = 0.018) and 12 months (z = -3.06, p = 0.002) post-notification compared to baseline. Genetic testing for mutations common in Ashkenazi Jewish women with result disclosure does not lead to adverse psychological outcomes.