Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance
Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance
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DOI：
10.1073/pnas.93.8.3704
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发表时间：
1996-04-16
影响因子：
11.1
通讯作者：
Cantilena, LR
中科院分区：
文献类型：
--
作者：
Levine, M;ConryCantilena, C;Cantilena, LR
维生素C的推荐膳食供给量（RDA）的决定因素包括维生素C剂量与稳态血浆浓度、生物利用度、尿排泄、细胞浓度和潜在不良反应之间的关系。由于目前的数据不足，进行了一项院内消耗-补充研究。七名健康志愿者住院4-6个月，并食用含有以下成分的饮食：
Determinants of the recommended dietary allowance (RDA) for vitamin C include the relationship between vitamin C dose and steady state plasma concentration, bioavailability, urinary excretion, cell concentration, and potential adverse effects. Because current data are inadequate, an in-hospital depletion-repletion study was conducted. Seven healthy volunteers were hospitalized for 4-6 months and consumed a diet containing