SLEEP-DEPRIVATION IN THE RAT .3. TOTAL SLEEP-DEPRIVATION
SLEEP-DEPRIVATION IN THE RAT .3. TOTAL SLEEP-DEPRIVATION
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DOI：
10.1093/sleep/12.1.13
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发表时间：
1989-02-01
期刊：
影响因子：
5.6
通讯作者：
RECHTSCHAFFEN, A
中科院分区：
文献类型：
--
作者：
EVERSON, CA;BERGMANN, BM;RECHTSCHAFFEN, A
10只大鼠采用圆盘法进行完全睡眠剥夺（TSD）。所有TSD大鼠在11-32天内死亡或死亡迫在眉睫时处死。未确定死亡的解剖学原因。尽管摄食量增加，但所有TSD大鼠均表现出虚弱的外观、尾巴和爪子上的病变以及体重减轻。他们的对照组（TSC）大鼠保持健康。由于排除了脱水，并且几项措施表明加速使用而不是未能吸收营养素，因此TSD大鼠的食物重量变化归因于能量消耗（EE）增加。基于食物、体重和废物的热量值的EE测量表明，所有TSD大鼠的EE增加，平均水平达到基线值的两倍以上。
Ten rats were subjected to total sleep deprivation (TSD) by the disk apparatus. All TSD rats died or were sacrificed when death seemed imminent within 11-32 days. No anatomical cause of death was identified. All TSD rats showed a debilitated appearance, lesions on their tails and paws, and weight loss in spite of increased food intake. Their yoked control (TSC) rats remained healthy. Since dehydration was ruled out and several measures indicated accelerated use rather than failure to absorb nutrients, the food-weight changes in TSD rats were attributed to increased energy expenditure (EE). The measurement of EE, based upon caloric value of food, weight, and wastes, indicated that all TSD rats increased EE, with mean levels reaching more than twice baseline values.