Combined uridine and choline administration improves cognitive deficits in spontaneously hypertensive rats
Combined uridine and choline administration improves cognitive deficits in spontaneously hypertensive rats
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DOI：
10.1016/s1074-7427(03)00024-8
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发表时间：
2003-07-01
影响因子：
2.7
通讯作者：
Broersen, LM
中科院分区：
文献类型：
--
作者：
De Bruin, NMWJ;Kiliaan, AJ;Broersen, LM
理由。高血压被认为是认知障碍发展的危险因素，因为它对脑血管和血流有负面影响。大鼠遗传性高血压与一系列认知障碍有关。因此，自发性高血压大鼠（SHR）可以潜在地用作人类受试者中认知缺陷的模型。因此，可以确定某些食物成分是否可以改善这些大鼠的认知能力。本研究旨在确定SHR是否表现出注意、学习和记忆功能的特异性缺陷。此外，慢性尿苷和胆碱管理的影响进行了研究。5-7将10月龄SHR与血压正常的Wistar-Kyoto（WKY）和Sprague-Dawley（SD）大鼠进行比较。(a)采用操作性延迟位置不匹配（DNMTP）测验研究短时记忆功能。(b)采用五选择系列反应时（5-CSRT）任务评估选择性视觉注意过程。(c)最后，莫里斯水迷宫（MWM）获取被用作空间学习和记忆能力的测量。结果。(1)SHR表现出显着受损的性能在5-CSRT测试相比，其他两个大鼠品系。与SD大鼠相比，SHR和WKY大鼠的空间学习能力均有所下降。(2)补充尿苷和胆碱使SHR在5-CSRT试验中的表现正常化。(3)此外，尿苷和胆碱治疗改善了WKY和SHR大鼠的MWM获得。结果表明，SHR在视觉选择性注意和空间学习方面存在缺陷。因此，自发性高血压可能提供一个有趣的模型，在筛选具有治疗潜力的物质治疗认知障碍。尿苷和胆碱的联合应用改善了SHR的选择性注意力和空间学习能力。(C)2003 Elsevier Science（美国）。All rights reserved.
Rationale. Hypertension is considered a risk factor for the development of cognitive disorders, because of its negative effects on cerebral vasculature and blood flow. Genetically induced hypertension in rats has been associated with a range of cognitive impairments. Therefore, spontaneously hypertensive rats (SHR) can potentially be used as a model for cognitive deficits in human subjects. Consecutively, it can be determined whether certain food components can improve cognition in these rats.Objective. The present study aimed to determine whether SHR display specific deficits in attention, learning, and memory function. Additionally, effects of chronic uridine and choline administration were studied.Methods. 5-7 months old SHR were compared with normotensive Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rats. (a) The operant delayed non-matching-to-position (DNMTP) test was used to study short-term memory function. (b) The five-choice serial reaction time (5-CSRT) task was used to assess selective visual attention processes. (c) Finally, the Morris water maze (MWM) acquisition was used as a measure for spatial learning and mnemonic capabilities.Results. (1) SHR exhibited significantly impaired performance in the 5-CSRT test in comparison with the two other rat strains. Both the SHR and WKY showed deficits in spatial learning when compared with the SD rats. (2) Uridine and choline supplementation normalized performance of SHR in the 5-CSRT test. (3) In addition, uridine and choline treatment improved MWM acquisition in both WKY and SHR rats.Conclusion. The present results show that the SHR have a deficiency in visual selective attention and spatial learning. Therefore, the SHR may provide an interesting model in the screening of substances with therapeutic potential for treatment of cognitive disorders. A combination of uridine and choline administration improved selective attention and spatial learning in SHR. (C) 2003 Elsevier Science (USA). All rights reserved.