Azithromycin failure in Mycoplasma genitalium urethritis
Azithromycin failure in Mycoplasma genitalium urethritis
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DOI：
10.3201/eid1207.051558
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发表时间：
2006-07-01
影响因子：
11.8
通讯作者：
Fairley, CK
中科院分区：
文献类型：
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作者：
Bradshaw, CS;Jensen, JS;Fairley, CK
我们报告了男性支原体生殖器阳性非淋菌性尿道炎患者服用1g阿奇霉素后的显著失败率(28%，95%可信区间15%-45%)。体外证据支持降低生殖支原体对大环内酯类抗生素的敏感性。所有病例服用莫西沙星后症状迅速缓解和感染消失。这些发现对尿道炎的治疗有一定的指导意义。
We report significant failure rates (28%, 95% confidence interval 15%-45%) after administering 1 g azithromycin to men with Mycoplasma genitalium-positive nongonococcal urethritis. In vitro evidence supported reduced susceptibility of M. genitalium to macrolides. Moxifloxacin administration resulted in rapid symptom resolution and eradication of infection in all-cases. These findings have implications for management of urethritis.