In vivo target-specific delivery of macromolecular agents with MR-guided focused ultrasound
In vivo target-specific delivery of macromolecular agents with MR-guided focused ultrasound
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DOI：
10.1148/radiology.204.1.9205257
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发表时间：
1997-07-01
期刊：
影响因子：
19.7
通讯作者：
Li, KCP
中科院分区：
文献类型：
--
作者：
Bednarski, MD;Lee, JW;Li, KCP
使用兔子肌肉中的磁共振（MR）图像来选择应用脉冲聚焦超声的目标区域。然后将封装钆喷塔酸二葡胺（一种代表药剂的 MR 可检测模型）的脂质体进行静脉注射。 T1 加权图像上的焦点增强（代表钆脂质体积累）发生在脉冲聚焦超声焦点区域。因此，磁共振引导的脉冲聚焦超声有针对性地在组织内输送大分子药剂。
Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentatate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed-focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.