The evolution of spliceosomal introns in alveolates.
The evolution of spliceosomal introns in alveolates.
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DOI：
10.1093/molbev/msm037
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发表时间：
2007-05
影响因子：
10.7
通讯作者：
Hung D. Nguyen;M. Yoshihama;N. Kenmochi
中科院分区：
文献类型：
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作者：
Hung D. Nguyen;M. Yoshihama;N. Kenmochi
许多关于剪接体内含子进化的问题仍然知之甚少。在这方面，重建深分枝物种如肺泡动物的内含子进化具有特殊的意义。在这项研究中，我们利用来自10个物种(9个牙槽动物和1个外群，智人)162个同源基因的3,368个内含子位置来推测牙槽动物的内含子进化。我们发现，虽然泰勒氏菌和疟原虫最近很少发生内含子的获得和丢失，但在泡状动物的进化过程中发生了许多内含子的获得和丢失。因此，内含子在肺泡中的获得和丢失的速率在时间和谱系上有很大的差异。我们的结果似乎支持这样的观点，即大量内含子的获得和丢失发生在较短的时期，可能与重大进化事件重合。
Many issues concerning the evolution of spliceosomal introns remain poorly understood. In this respect, the reconstruction of the evolution of introns in deep branching species such as alveolates is of special significance. In this study, we inferred the intron evolution in alveolates using 3,368 intron positions in 162 orthologs from 10 species (9 alveolates and 1 outgroup, Homo sapiens). We found that although very few intron gains and losses have occurred in Theileria and Plasmodium recently, many intron gains and losses have occurred in the evolution of alveolates. Thus, the rates of intron gain and loss in alveolates have varied greatly across time and lineage. Our results seem to support the notion that massive intron gains and losses have occurred during short episodes, perhaps coinciding with major evolutionary events.