Mitotic inheritance of genetic and epigenetic information via the histone H3.1 variant.
Mitotic inheritance of genetic and epigenetic information via the histone H3.1 variant.
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DOI：
10.1016/j.pbi.2023.102401
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发表时间：
2023-06
影响因子：
9.5
通讯作者：
Valentin Joly;Yannick Jacob
中科院分区：
文献类型：
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作者：
Valentin Joly;Yannick Jacob
在多细胞真核生物中普遍存在的复制依赖性组蛋白H3.1变体，由于其独特的表达模式仅限于细胞周期的S期，已被提出在染色质复制过程中发挥关键作用。在这里，我们描述了最近在植物中发现的分子机制和细胞途径，涉及H3.1，有助于维护基因组和表观基因组信息。首先，我们强调了关于组蛋白伴侣CAF-1和TSK-H3.1 DNA修复途径在防止复制过程中基因组不稳定性方面的贡献的新进展。然后，我们总结的证据连接H3.1的有丝分裂遗传的表观遗传状态所需的特定角色。最后，我们讨论了最近确定的H3.1和DNA聚合酶之间的特定相互作用及其功能的影响。
The replication-dependent histone H3.1 variant, ubiquitous in multicellular eukaryotes, has been proposed to play key roles during chromatin replication due to its unique expression pattern restricted to the S phase of the cell cycle. Here, we describe recent discoveries in plants regarding molecular mechanisms and cellular pathways involving H3.1 that contribute to the maintenance of genomic and epigenomic information. First, we highlight new advances concerning the contribution of the histone chaperone CAF-1 and the TSK-H3.1 DNA repair pathway in preventing genomic instability during replication. We then summarize the evidence connecting H3.1 to specific roles required for the mitotic inheritance of epigenetic states. Finally, we discuss the recent identification of a specific interaction between H3.1 and DNA polymerase epsilon and its functional implications.