Macrophage Cell Membrane Camouflaged Au Nanoshells for in Vivo Prolonged Circulation Life and Enhanced Cancer Photothermal Therapy
Macrophage Cell Membrane Camouflaged Au Nanoshells for in Vivo Prolonged Circulation Life and Enhanced Cancer Photothermal Therapy
复制标题
巨噬细胞膜伪装金纳米壳可延长体内循环寿命并增强癌症光热治疗
DOI：
10.1021/acsami.6b00853
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发表时间：
2016-04-20
影响因子：
9.5
通讯作者：
He, Qiang
中科院分区：
文献类型：
--
作者：
Xuan, Mingjun;Shao, Jingxin;He, Qiang
巨噬细胞膜（MPCM）包裹的金纳米壳（AuNS）可以作为新一代光热转换剂用于体内光热治疗癌症。它们是通过生物相容性AuNS和MPCM囊泡的融合构建的。所得MPCM包覆AuNS具有良好的胶体稳定性，并保持了AuNS原有的近红外（NIR）吸附。由于金纳米颗粒表面覆盖了高密度的MPCMs，因此将巨噬细胞膜的全部功能部分移植到金纳米颗粒表面。这种表面功能化通过识别肿瘤内皮提供了主动靶向能力，因此与红细胞膜涂覆方法相比改善了致瘤性积聚。这些生物力学纳米颗粒显着增加体内血液循环时间和局部积聚在肿瘤时，系统地管理。在NIR激光照射时，由MPCM涂覆的AuNS产生的局部热实现了高效率，以抑制肿瘤生长并选择性地消融照射区域内的癌细胞。因此，MPCM包裹的AuNS保持了其源细胞的天然性质，这可能会提高AuNS和其他贵金属纳米颗粒调节的光热治疗的效果。
Macrophage cell membrane (MPCM)-camouflaged gold nano shells (AuNS) that can serve as a new generation of photothermal conversion agents for in vivo photothermal cancer therapy are presented. They are constructed by the fusion of biocompatible AuNSs and MPCM vesicles. The resulting MPCM-coated AuNSs exhibited good colloidal stability and kept the original near-infrared (NIR) adsorption of AuNSs. Because AuNS carried high density coverage of MPCMs, the totally functional portions of macrophage cells membrane were grafted onto the surface of AuNSs. This surface functionalization provided active targeting ability by recognizing tumor endothelium and thus improved tumoritropic accumulation compared to the red blood cell membrane coating approach. These biomirnetic nanoparticles significantly enhance in vivo blood circulation time and local accumulation at the tumor when administered systematically. Upon NIR laser irradiation, local heat generated by the MPCM-coated AuNS achieves high efficiency to suppress tumor growth and selectively ablate cancerous cells within the illuminated zone. Therefore, MPCM-coated AuNSs remained the natural properties of their source cells, which may improve the efficacy of photothermal therapy modulated by AuNSs and other noble-metal nanoparticles.