Towards improved clinical and physiological assessments of recovery in spinal cord injury: a clinical initiative
Towards improved clinical and physiological assessments of recovery in spinal cord injury: a clinical initiative
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改善脊髓损伤恢复的临床和生理评估：一项临床举措
DOI：
10.1038/sj.sc.3101596
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发表时间：
2004
期刊：
影响因子：
2.2
通讯作者：
S. Theodorou
中科院分区：
文献类型：
--
作者：
P. Ellaway;P. Anand;E. Bergstrom;M. Catley;N. Davey;H. Frankel;A. Jamous;C. Mathias;A. Nicotra;G. Savić;D. Short;S. Theodorou
临床实践和科学研究可能很快导致旨在修复脊髓损伤的治疗方法。在第一次试验中，修复可能是部分的，仅在原始损伤下方延伸一到两个节段。此外，目前可用的治疗方法可能会应用于胸脊髓，以尽量减少因幸存连接受损而导致的功能丧失。这些附带条件促进了对临床和生理测试的改进的研究，所述临床和生理测试被设计为（1）确定脊髓损伤的水平和密度，（2）提供对一个或两个脊髓节段的恢复的可靠监测，以及（3）提供由胸脊神经根支配提供的功能的指数，所述功能目前在脊髓损伤的评估中被很大程度地忽视。本文综述了由国际脊柱研究信托基金会发起的临床倡议的进展，以推进实现这些目标所需的感觉，运动和自主神经功能的临床和生理测试。
Clinical practice and scientific research may soon lead to treatments designed to repair spinal cord injury. Repair is likely to be partial in the first trials, extending only one or two segments below the original injury. Furthermore, treatments that are becoming available are likely to be applied to the thoracic spinal cord to minimise loss of function resulting from damage to surviving connections. These provisos have prompted research into the improvement of clinical and physiological tests designed (1) to determine the level and density of a spinal cord injury, (2) to provide reliable monitoring of recovery over one or two spinal cord segments, and (3) to provide indices of function provided by thoracic spinal root innervation, presently largely ignored in assessment of spinal cord injury. This article reviews progress of the Clinical Initiative, sponsored by the International Spinal Research Trust, to advance the clinical and physiological tests of sensory, motor and autonomic function needed to achieve these aims.