CENTROMERES OF BUDDING AND FISSION YEASTS
CENTROMERES OF BUDDING AND FISSION YEASTS
复制标题
DOI：
10.1016/0168-9525(90)90149-z
复制
发表时间：
1990-05-01
影响因子：
11.4
通讯作者：
CLARKE, L
中科院分区：
文献类型：
--
作者：
CLARKE, L
高级真核生物染色体的着丝粒是一个复杂的、多功能的区域，包括着丝点或纺锤体附着位点，以及通常广泛的跨许多kb DNA的周中心异色重复DNA序列。有丝点区域在有丝分裂和减数分裂的中期为纺锤体纤维提供附着位点，并在后期染色单体的运动中起作用。着丝粒在有丝分裂中期和整个第一次减数分裂过程中也保持姐妹染色单体的附着。因此，着丝粒在有丝分裂和减数分裂中负责染色体的适当分离，从而确保遗传信息平等地分配给下一代体细胞或生殖系细胞。高等真核生物中着丝粒DNA的复杂性促使了对更简单的真核生物系统中染色体分离的研究，预计较小的染色体大小可能需要相应的较不复杂的着丝粒区域，这将更容易使用标准分子遗传技术进行分析。
The centromere of a higher eukaryotic chromosome is a complex, multifunctional region that includes the kinetochore or spindle attachment site (s) and often extensive pericentric heterochromatic repeated DNA sequences that span many ktlobase pairs (kb) of DNA. The specialized kinetochore region provides an attachment site in metaphase for mitotic and meiotic spindle fibers and functions in the movement of the chromatids at anaphase. The centromere also maintains sister chromatid attachment in mitotic metaphase and throughout the first meiotic division. Thus, the centromere is responsible for the proper segregation of chromosomes in mitosis and meiosis, thereby ensuring equal distribution of genetic information to the next generation of somatic or germ-line cells. The complexity of centromere DNA in higher eukaryotes has prompted research on chromosome segregation in more simple eukaryotic systems, where it was anticipated that a smaller chromosome size might require a correspondingly less complex centromere region that would be easier to analyse using standard molecular genetic techniques.