[An experimental study of a cyanoacrylate biological adhesive in view of its use in the fixation of various fractures of the fingers].
[An experimental study of a cyanoacrylate biological adhesive in view of its use in the fixation of various fractures of the fingers].
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DOI：
10.1016/s0753-9053(97)80035-x
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发表时间：
1997-01-01
期刊：
影响因子：
--
通讯作者：
Maiorana, A
中科院分区：
文献类型：
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作者：
Caroli, A;Marcuzzi, A;Maiorana, A
根据十九世纪六十年代至今研究人员在出版物中报道的一些有趣的结果，我们决定试验一种具有高粘合性能的特殊粘合剂：它由 α-氰基丙烯酸乙酯-2-α-氰基丙烯酸酯单体组成。为此，对15只4个月左右、体重2公斤的成年鸡进行了实验，分为5组，每组3只鸡。在每只鸡中，制备来自胫骨近端中间三分之一的矩形骨碎片，完全分离，然后重新定位并用粘合剂和胶原蛋白固定。按照预先设定的时间间隔（7、14、21、30和60天），对每组鸡进行X射线检查，然后将其处死，以便对检查中的特定解剖部位进行微观和宏观研究。这些实验的目的是评估氰基丙烯酸酯粘合剂确保小骨碎片固定的能力，否则这些骨碎片会不稳定。获得的结果表明：骨碎片稳定性良好；良好的骨巩固；无异物反应。这些结果的积极性质促使我们建议在手部手术中使用这种粘合剂。然而，职责要求进行进一步的实验，以便为所获得的积极结果获得更大的保证。
Following certain interesting results reported in publications by researchers from the nineteen-sixties up to the present time, we decided to experiment a particular adhesive with high adhesive properties: this is composed of monomers of alpha-cyanoacrylate ethyl-2-alpha-cyanoacrylate. For this end, experiments were performed on 15 adult chickens, aged around 4 months, weighing 2 kg, divided into 5 groups of 3 chickens each. In each chicken, a rectangular bone fragment from the proximal-middle third of the tibia was prepared, completely separated, and then subsequently re-positioned and fixed with the adhesive plus collagen. At pre-established intervals (7, 14, 21, 30 and 60 days), each group of chickens was examined by x-rays and then killed, so that the particular anatomical part under examination could be studied both microscopically and macroscopically. The aim of these experiments was to evaluate the ability of cyanoacrylate adhesive to ensure setting of small bone-fragments that would otherwise be unstable. The results obtained showed the following: good stability of the bone fragment; good bone consolidation; absence of foreign body reactions. The positive nature of these results leads us to propose the use of this adhesive in hand surgery. Nevertheless, duty requires that further experiments be performed in order to acquire even greater guarantees for the positive results obtained.