A novel method to assess the severity and prognosis in crush syndrome by assessment of skin damage in hairless rats.
A novel method to assess the severity and prognosis in crush syndrome by assessment of skin damage in hairless rats.
复制标题
一种通过评估无毛大鼠皮肤损伤来评估挤压综合征严重程度和预后的新方法。
DOI：
10.1007/s00068-018-0987-7
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Kanamoto I
中科院分区：
文献类型：
--
作者：
Murata I;Kawanishi R;Inoue S;Iwata M;Kobayashi J;Inoue Y;Kanamoto I
目的挤压综合征（CS）是一种严重的医学疾病，其特征是由于压力导致的肌肉细胞损伤，即使患者在转运到医院或入院期间接受液体治疗，也与高死亡率相关。由于缺乏流行病学和定量数据，对地震挤压伤伤员没有标准的分诊方法。我们研究了是否可以根据皮肤损伤的严重程度预测死亡率，以便通过评估无毛大鼠的皮肤损伤来评估挤压综合征的严重程度和预后，因为我们先前已经观察到CS导致大鼠皮肤水肿和发红。用橡皮止血带止血5 h。然后将大鼠随机分为三组：假手术，轻度CS，和严重CS.ResultsThe轻度和重度CS组的死亡率分别为20和90%。重度CS组表现出较高的高钾血症、低血容量性休克、酸中毒和炎症发生率。与轻度CS组相比，重度CS组的皮肤损伤明显更严重。皮肤损伤表现出良好的相关性与病理severity.ConclusionsSkin损伤是一个有效的措施，经皮水分损失和严重程度的CS。我们建议，这些模型可能是有用的专业人员谁是没有经验的灾害管理，以确定地震灾民的严重CS的高风险。
PurposeCrush syndrome (CS), a serious medical condition characterised by damage to the muscle cells due to pressure, is associated with high mortality, even when patients receive fluid therapy during transit to the hospital or admission to the hospital. There is no standard triage approach for earthquake victims with crush injuries due to the scarcity of epidemiologic and quantitative data. We examined whether mortality can be predicted based on the severity of skin damage so that assess the severity and prognosis in crush syndrome by assessment of skin damage in hairless rats because we have previously observed that CS results in oedema and redness of the skin in rats.MethodsAnaesthetised rats were subjected to bilateral hind limb compression [1 kg (mild) and 2 kg (severe) loads] with a rubber tourniquet for 5 h. The rats were then randomly divided into three groups: sham, mild CS, and severe CS.ResultsThe mild and severe CS groups had mortality rates of 20 and 90%, respectively. The severe CS group demonstrated higher rates of hyperkalaemia, hypovolemic shock, acidosis, and inflammation. Skin damage was significantly worse in the severe CS group compared to the mild CS group. Skin damage showed good correlation with pathological severity.ConclusionsSkin damage is a valid measure of transepidermal water loss and severity of CS. We suggest that these models may be useful to professionals who are not experienced in disaster management to identify earthquake victims at high risk of severe CS.