Cortical substrates of taste aversion learning: dorsal prepiriform (insular) lesions disrupt taste aversion learning.
Cortical substrates of taste aversion learning: dorsal prepiriform (insular) lesions disrupt taste aversion learning.
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味觉厌恶学习的皮质基质：背侧梨前状（岛状）病变破坏味觉厌恶学习。
DOI：
10.1037/h0077894
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Glanzman,DL
中科院分区：
文献类型：
--
作者：
Lasiter,PS;Glanzman,DL
通过行为学和神经组织学技术的结合，研究了腹侧初级躯体感觉新皮层的限制性损伤与大鼠获得条件性味觉厌恶（CTA）的能力之间的功能关系。受试者为84只雄性Long-Evans hooded大鼠。仅限于已建立的味觉新皮层（GN）的病变并没有破坏CTA采集，也没有局限于GN腹侧的喉上皮层区域的病变。病变侵犯背侧梨状前体和岛叶皮质产生CTA采集缺陷，并损坏了很大比例的传出投射到前额叶和中央前区新皮质。背侧梨状前皮质和岛叶皮质的病变并没有改变任何4种味觉模式的味觉偏爱-厌恶阈值。它的结论是，腹侧体感新皮层领域，包括建立GN，不介导CTA收购和鼻皮质腹侧和后GN优先参与联想学习的口味和疾病。(51参考）（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
The functional relation between restricted damage to ventral primary somatosensory neocortex and the ability of rats to acquire conditioned taste aversions (CTA) was examined by a combination of behavioral and neurohistological techniques. Ss were 84 male Long-Evans hooded rats. Lesions confined exclusively to the established gustatory neocortex (GN) did not disrupt CTA acquisition, nor did lesions confined to suprarhinal cortical areas ventral to the GN. Lesions that encroached on dorsal prepiriform and insular cortices produced CTA acquisition deficits and damaged a large proportion of efferent projections to the prefrontal and precentral neocortex. Lesions of dorsal prepiriform and insular cortices did not modify taste preference–aversion thresholds to any of the 4 taste modalities. It is concluded that ventral somatosensory neocortical fields, including the established GN, do not mediate CTA acquisition and that rhinal cortices ventral and posterior to the GN are preferentially involved in associative learning for tastes and illness.(51 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)