A method for filling complex polymeric microfluidic devices and arrays
A method for filling complex polymeric microfluidic devices and arrays
复制标题
DOI：
10.1021/ac001426z
复制
发表时间：
2001-07-01
影响因子：
7.4
通讯作者：
Nuzzo, RG
中科院分区：
文献类型：
--
作者：
Monahan, J;Gewirth, AA;Nuzzo, RG
本文描述了一种改进的方法，用于填充微流体结构与水溶液。该方法，通道除气技术（COT），是基于在减压下进行的填充程序。该程序与先前报道的方法相比，其中微流体通道通过使用毛细作用力或通过在一个或多个空的储液器处施加压力梯度来填充。该技术已被证明在消除微流体网络内气泡形成方面的有效性> 90%。它可以应用于许多设备，包括包含PDM端接通道特征、单通道入口和三维阵列的设备。
This paper describes an improved method for filling microfluidic structures with aqueous solutions. The method, channel outgas technique (COT), is based on a filling procedure carried out at reduced pressures. This procedure is compared with previously reported methods in which microfluidic channels are filled either by using capillary forces or by applying a pressure gradient at one or more empty reservoirs. The technique has proven to be > 90% effective in eliminating the formation of bubbles within microfluidic networks. It can be applied to many devices, including those containing PDMS-terminated channel features, a single channel inlet, and three-dimensional arrays.