The Effect of In-Utero Conditions on Long Term Health: Evidence from the 1918 Spanish Flu Pandemic
The Effect of In-Utero Conditions on Long Term Health: Evidence from the 1918 Spanish Flu Pandemic
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子宫内状况对长期健康的影响：来自 1918 年西班牙流感大流行的证据
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Craig L. Garthwaite
中科院分区：
文献类型：
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作者：
Craig L. Garthwaite
胎儿起源假说认为，子宫内压力增加了以后生活中慢性病的发病率。利用21年的全国健康访谈调查数据，这项研究估计了子宫内暴露于1918年西班牙流感大流行对健康的影响。利用人们在胎儿发育的不同阶段接触流感的事实，该模型测试了医学文献中关于子宫内接触流感会在什么时候损害以后的器官的准确预测。结果的模式证明了使用短时间事件作为胎儿条件变异来源的必要性，并有助于解释先前关于胎儿起源假说的混合证据。
The fetal origins hypothesis posits that in-utero stress increases the incidence of chronic conditions later in life. Utilizing 21 years of National Health Interview Survey data, this study estimates the health effect of in-utero exposure to the 1918 Spanish Flu pandemic. Exploiting t he fact that people were exposed to the flu at different points during fetal development, the model tests precise predictions from the medical literature about when exposure to in utero insults should damage organs later in life. The pattern of results demonstrates the necessity of using a short duration event as a source of variation in fetal conditions and helps explain previously mixed evidence regarding the fetal origins hypothesis.
影响因子：
7.7
作者：
Simmons, RA;Templeton, LJ;Gertz, SJ
通讯作者：
Gertz, SJ
影响因子：
2.5
作者：
Nathanielsz, PW
通讯作者：
Nathanielsz, PW
影响因子：
5.4
作者：
Elo, IT;Preston, SH
通讯作者：
Preston, SH