Fibroblast growth factor-2 alters the nature of extinction
Fibroblast growth factor-2 alters the nature of extinction
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DOI：
10.1101/lm.2006511
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发表时间：
2011-02-01
影响因子：
2
通讯作者：
Richardson, Rick
中科院分区：
文献类型：
--
作者：
Graham, Bronwyn M.;Richardson, Rick
这些实验检测了NMDA受体（NMDAr）拮抗剂MK 801对条件性恐惧的重新获得和重新消退的作用，所述条件性恐惧在注射成纤维细胞生长因子-2（FGF 2）或载体之前已经消退。最近的研究结果表明，再学习和再灭绝，不像初始学习和灭绝，不依赖于NMDAR激活。三个实验表明，FGF 2阻止从NMDAr依赖性到NMDAr非依赖性的再获取和再消退的转换，这表明FGF 2可能导致原始恐惧记忆的部分擦除。这些发现增加了越来越多的工作，表明FGF 2可能是一种新的药理学增强剂，用于焦虑症患者的暴露治疗。
These experiments examined the effects of the NMDA-receptor (NMDAr) antagonist MK801 on reacquisition and re-extinction of a conditioned fear that had been previously extinguished before injection of fibroblast growth factor-2 (FGF2) or vehicle. Recent findings have shown that relearning and re-extinction, unlike initial learning and extinction, do not depend on NMDAr activation. Three experiments demonstrated that FGF2 prevents the switch from NMDAr-dependent to NMDAr-independent reacquisition and re-extinction, suggesting that FGF2 may lead to the partial erasure of the original fear memory. These findings add to a growing body of work suggesting that FGF2 may be a novel pharmacological enhancer of exposure therapy for humans with anxiety disorders.