Interpretation of pathogen load in relationship to infectivity and pathogen reduction efficacy.
Interpretation of pathogen load in relationship to infectivity and pathogen reduction efficacy.
复制标题
解释病原体负荷与感染性和病原体减少功效的关系。
DOI：
10.1111/trf.15103
复制
发表时间：
2019
期刊：
影响因子：
2.9
通讯作者：
Ness,PaulM
中科院分区：
文献类型：
--
作者：
McCullough,Jeffrey;Alter,HarveyJ;Ness,PaulM
病原体减少技术（PRT）的基本概念是能够减少病原体，从而降低输血传播感染的风险，同时保持组成血细胞的完整性。PRT的主要考虑因素不仅是最大杀伤能力，而且还包括PRT在可能通过供体医学筛查过程的无症状个体中预期的传染性病原体水平方面的表现。在这篇综述中，我们总结了传染性病原体的循环水平和这些水平的感染性的可能性。这与影响特定血液制品感染可能性的其他因素有关。
The fundamental concept in pathogen reduction technology (PRT) is the ability to inactivate patho-gens and thus reduce the risk of transfusiontransmitted infections while maintaining the integrity of constituent blood cells. The main consideration in PRT is not only the maximum killing capacity but also how PRT performs in relation to the levels of infectious agents that can be expected in asymptomatic individuals who could pass the donor medical screening process. In this review we summarize the circulating levels of infectious agents and the likelihood of infectivity from these levels. This is put in context with other factors that influence the likelihood of infections from a particular blood product.